Results 211 to 220 of about 281,327 (265)

A Citrulline‐Functionalized Patch Coordinates Macrophage NRF2 Signaling and Arginine Metabolism for Tendon‐to‐Bone Repair

Advanced Science, EarlyView.
A locally implanted patch combines citrulline‐functionalized carbon dots, a thioketal‐containing membrane coating from tendon‐derived stem cells, and aligned core–shell fibers. In macrophages, the patch reduces inflammatory markers and enhances antioxidant signaling through nuclear factor erythroid 2‐related factor 2 (NRF2); in rats and rabbits, it ...
Yuhao Yu, Wencai Liu, Xinyue Yang, Hanzhe Zhang, Hui Xu, Xin Wang, Weimin Lin, Xiping Jiang, Chenrui Yuan, Yifei Wang, Weilin Yu, Yamin Li, Wei Song, Yaohua He   +13 more
wiley   +1 more source

A Bioengineered Mitochondrial Respiration‐Mimetic Copper‐Based Metal‐Organic Framework Reprogramming Oxidative Phosphorylation to Enhance Tumor Cuproptosis

Advanced Science, EarlyView.
A bioengineered mitochondrial respiration‐mimetic nanoplatform (TC@OMG) renews tumor mitochondrial metabolism to enhance cuproptosis. TC@OMG integrates a copper‐based metal‐organic framework co‐loaded with glucose oxidase and a lactate dehydrogenase inhibitor, and is cloaked with a hybrid membrane derived from tumor cells and plant thylakoids, enabling
Liyang Zhou, Hongpei Deng, Tingli Zheng, Huan Min, Qiwei Tian, Huimin Lin, Jing Ruan, Xianqun Fan   +7 more
wiley   +1 more source

A Celastrol–Platinum(IV) Nanoprodrug Couples Ferroptosis With Caspase‐Independent Pyroptosis to Enhance Anti‐PD‐1 Therapy in Colorectal Cancer

Advanced Science, EarlyView.
CPAN integrates celastrol‐driven oxidative stress with Pt(IV)‐induced DNA damage to couple ferroptosis with caspase‐independent pyroptosis. Celastrol disrupts the GSH/GPX4 axis and promotes lipid peroxidation, while Pt(IV)‐associated PARP/PARylation signaling facilitates full‐length GSDME oligomerization.
Huirong Li, Wenxiang Feng, Le Xin, Wu Zhong, Zhuhuai Peng, Zhihong Ke, Wenbin Zhou, Yutong Wu, Ying Chen, Hongwei Wang, Jidong Liu, Jinjun Ye, Weihong Guo   +12 more
wiley   +1 more source

Short-Term Outcomes of an Investigational Hybrid Polymer-Hyaluronic Acid Filler for Nonsurgical Rhinoplasty: An Uncontrolled Pilot Study. [PDF]

Clin Cosmet Investig Dermatol
Chen HK, Liu HC, Lin HJ, Wu D.
europepmc   +1 more source

Bacillus Licheniformis‐Induced Cognitive Decline in Mice Linking Gut Microbiota Dysbiosis, Metabolic Perturbations, and Hippocampal Neuroinflammation

Advanced Science, EarlyView.
Chronic oral administration of specific probiotic strains triggers gut microbiota dysbiosis and systemic metabolic perturbations in mice. Multi‐omics profiling reveals subsequent hippocampal glial remodeling and neuroinflammation, which are linked to cognitive impairment.
Yibin Lin, Afeng Wang, Hongchang Zhou, Yuliang Sun, Yingying Guo, Keyu Chen, Junhong Sun, Tinliang Lin, Zhaochen Huang, Xinhua Qiang, Jie He, Jianlin Lou, Yunliang Yao, Shengwen Shao, Yongliang Pan, Xiang Wang   +15 more
wiley   +1 more source

Diagnostic approaches for tubal factor infertility: a systematic review of HSG, HyCoSy, HyFoSy, and laparoscopy. [PDF]

Front Reprod Health
Alenova A, Kauysheva A, Korkan A, Magalov I.   +3 more
europepmc   +1 more source

Localized Hydrogen Release Driven by Mg–Pd Microgalvanic Cells from 3D‐Printed Microneedles Reverses Redox Homeostasis for Psoriasis Treatment

Advanced Science, EarlyView.
A 3D printing microneedle (MP‐MN), loading magnesium‐based micro‐galvanic cells (MP), is designed for improving psoriasis. H2 generated from MP‐MN scavenges ROS and •OH, actives NRF2‐KEAP1 pathway, and decreases inflammation, thereby effectively restoring the oxidative stress homeostasis of psoriatic skin and suppressing the excessive proliferation of ...
Xinyue Shao, Zongyan He, Ning Yang, Lixuan Yin, Xujie Sun, Jingtong Qi, Xiaolong Feng, Yihui Zhang, Yiran Liu, Zhengwei Huang, Tianqun Lang   +10 more
wiley   +1 more source

Tactile perception and tolerability thresholds of TMS characterized by intensity across locations and frequencies. [PDF]

Clin Neurophysiol Pract
Nesmith N, Senda M, Hou Y, Dev K, Spitz AM, Kozel FA, Johnson KA.   +6 more
europepmc   +1 more source

Ligand‐Ratio–Tuned DNA Nanocarriers Overcome Bladder Barriers for Ultralow‐Dose Intravesical Therapy

Advanced Science, EarlyView.
A programmable DNA framework drug carrier coordinates barrier transport, tumor targeting, and drug delivery through ligand‐ratio engineering. Systematic exploration of the Sgc8/fluorocarbon design space reveals a nonlinear optimal balance between penetration and cellular engagement, translating multifunctional integration into durable bladder tumor ...
Dunfang Liu, Xiao Chen, Hongliang Bao, Qian Xia, Gang Huang, Yang Yang   +5 more
wiley   +1 more source