Results 221 to 230 of about 281,327 (265)

Pharmacokinetic Tuning Redirects β‐Lapachone From NQO1 Bioactivation to Vimentin‐Targeted Oxidation in Cancer

Advanced Science, EarlyView.
Pharmacokinetic tuning acts as a programmable mechanistic switch for β‐lap. Sustained low‐concentration exposure redirects β‐lap from NQO1 bioactivation to direct oxidation of vimentin, driving disulfide crosslinking, proteasomal overload and ferroptosis.
Lei Dou, Huiqin Liu, Kaixin Wang, Yi Xia, Zhidong Chen, Feng Qian   +5 more
wiley   +1 more source

Same Drugs, Different Clinical Questions: Concurrent Combination Versus Sequential Add-On Therapy in Neuropathic Pain. [PDF]

Eur J Pain
Sokmen O.
europepmc   +1 more source

Targeting a Calcium‐Associated Mitochondrial Vulnerability in TET2‐Deficient Myeloid Cells

Advanced Science, EarlyView.
Reduced TET2 function creates a calcium‐associated mitochondrial vulnerability in macrophages that is preferentially exploited by Lanatoside C. The resulting stress promotes apoptosis of TET2‐deficient macrophages, reduces inflammatory and fibrotic injury in human cardiac organoids, and highlights a genotype‐associated myeloid liability that may be ...
Yue Wang, Minh Duc Pham, Despina Stefanoska, Ting Yuan, Arka Provo Das, Chaonan Zhu, Meiqian Wu, Thanh Thuy Duong, Jaskiran Kaur, Yu Hao, Johannes Krefting, Marius Schwab, Jonathan Ward, Maria Duda, Wesley Abplanalp, Moritz von Scheidt, Andreas M. Zeiher, Stefanie Dimmeler, Jaya Krishnan   +18 more
wiley   +1 more source

Dose optimization strategies for abemaciclib: insights from the TRADE trial. [PDF]

Transl Breast Cancer Res
Nogueira LR, Bianchi MA, Ciruelos E.
europepmc   +1 more source

Exploiting Temperature Effects for Robust Control and Reference Circuits Using Thin‐Film Contact‐Controlled Transistors

Advanced Electronic Materials, EarlyView.
Compact circuits based on contact‐controlled transistors are well‐suited to unsupervised thermal management, sensitive temperature measurement, or temperature‐stable current references. Demonstrated on flexible microcrystalline silicon and supported by simulation, the approach does not require supply voltage regulation, remains manufacturable across ...
Eva Bestelink, Jean‐Charles Fustec, Olivier de Sagazan, Rogier Fransen, George Bairaktatis, Emmanuel Jacques, Radu A. Sporea   +6 more
wiley   +1 more source

Dermocosmetics for Periocular Aging: Evidence, Mechanisms, and Integration with Aesthetic Procedures. A Narrative Review. [PDF]

Dermatol Ther (Heidelb)
Prudkin L, Piquero-Casals J, Rengifo-Palacios J, Maleh D, Brown A, Steiner D, López Estebaranz JL.   +6 more
europepmc   +1 more source

Achievement of the Ideal Outcome After Pancreatectomy for Pancreatic Ductal Adenocarcinoma Is Associated With Earlier Initiation and Higher Completion Rates of Adjuvant Chemotherapy and Improved Long‐Term Survival

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Ideal Outcome is a composite quality indicator reflecting optimal postoperative course after pancreatic surgery. This study aimed to clarify the prognostic significance of achieving the Ideal Outcome and its influence on the initiation and completion of adjuvant chemotherapy.
Ryosuke Fukushima, Kenichiro Araki, Ryo Muranushi, Kouki Hoshino, Kei Hagiwara, Shunsuke Kawai, Mariko Tsukagoshi, Takamichi Igarashi, Norio Kubo, Ken Shirabe   +9 more
wiley   +1 more source

Minimally invasive, ultrasound-guided synovial tissue biopsies are well-tolerated, safe and feasible in children and young people with inflammatory arthritis. [PDF]

RMD Open
Clay E, Bolton C, Hackland A, Smith CG, Kupiec K, Kelly J, Chippington S, Sheikh Z, Foley C, Reis Nisa P, Lomholt S, Alexiou V, Turtsevich I, Pils C, Sultan S, Khan N, Thyagarajan M, Neag G, Mahony CB, Adams HR, Cotter C, Sadler M, Nguyen H, Barklam EB, Jones LJ, Chin PS, Kemble S, Marsh LJ, Davis P, Davda S, Compeyrot-Lacassagne S, Patel F, Rosser EC, Hanlon MM, Coles W, Dicarlo E, Gravallese E, Filer A, Al-Abadi E, Wedderburn LR, Croft AP.   +40 more
europepmc   +1 more source