Results 201 to 210 of about 281,327 (265)

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

From Multiple Treatment Failures to Functional Improvement With Lower-Sodium Oxybate in Idiopathic Hypersomnia: A Case Report. [PDF]

Cureus
Pham B.
europepmc   +1 more source

Topology‐Driven X‐Shaped DNA as a cGAS Stimulator to Promote Dendritic Cell Activation and Antitumor Vaccine Efficacy

Advanced Science, EarlyView.
X‐shaped DNA promotes multivalent cGAS assembly and enhances cGAS‐STING signaling. When conjugated with antigenic peptides, the resulting X‐DNA‐based peptide vaccine promotes dendritic cell activation, antigen presentation, and antitumor T‐cell responses.
Jiabei Li, Xuan Wang, Dali Wei, Zhejie Chen, Ziyi Wang, Qing Yu, Yu Yang, Shengpeng Wang   +7 more
wiley   +1 more source

Incretin-Based Therapies as Cardiometabolic Interventions: Outcome Hierarchy, Receptor-Network Pharmacology and Phenotype-Based Clinical Positioning. [PDF]

Diabetes Obes Metab
Sztanek F, Lőrincz H, Harangi M, Nagy AC.   +3 more
europepmc   +1 more source

A Damage‐Gated Small‐Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy

Advanced Science, EarlyView.
MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov, Ekaterina А. Guseva, Alexander Yu. Rudenko, Konstantin G. Lyamzaev, Sofya Y. Sokolskaya, Julia A. Golubeva, Maria V. Belopolskaya, Nadezda V. Andrianova, Olga V. Fadeeva, Elena О. Morgun, Elena A. Tukhovskaya, Marina S. Kazakova, Vladimir M. Pavlov, Daria K. Yagoda, Elena I. Marusich, Rose‐Lys Zaranaina, Valeriya B. Vays, Irina M. Vangeli, Egor Y. Plotnikov, Maxim L. Lovat, Lora E. Bakeeva, Arkady N. Murashev, Vladimir I. Polshakov, Olga A. Dontsova, Peter V. Sergiev   +24 more
wiley   +1 more source

Correction to: Safety, Tolerability, and Immunogenicity of Revaccination With mRNA-1345 RSV Vaccine Administered 24 Months Following a Primary Dose in Adults ≥60 Years of Age. [PDF]

J Infect Dis
europepmc   +1 more source

Effectiveness and safety of cannabidiol in adult patients with epilepsy: A multicenter, retrospective study. [PDF]

Epilepsia Open
Sánchez-Gamino S, Chamorro Muñoz MI, Serrano-Castro PJ, Hernández-Vitorique P, Rodríguez Jiménez L, López Moreno Y, Cabezudo-García P, García Martín G.   +7 more
europepmc   +1 more source

Bioorthogonal Click‐to‐Disassemble Phthalocyanine Nanoassemblies for Precise Chemo‐Photodynamic Therapy against Hypoxic Tumors

Advanced Science, EarlyView.
A bioorthogonal “click‐to‐disassemble” strategy enables precise activation of self‐assembled phthalocyanine nanoassemblies for chemo‐photodynamic therapy. EGFR‐targeted activator triggers IEDDA‐mediated disruption of the quenched assemblies, restoring fluorescence and ROS generation while releasing tirapazamine.
Jiaxin Shen, Evelyn Y. Xue, Caixia Yang, Peter Chi Keung Cheung, Dennis K. P. Ng   +4 more
wiley   +1 more source

Correction to: Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial. [PDF]

J Infect Dis
europepmc   +1 more source

Real-World Evidence for Existing Anti-Obesity Therapies-The Realities of Treatment Adherence, Tolerability, Access and Patient Satisfaction. [PDF]

Diabetes Obes Metab
Kassem S.
europepmc   +1 more source