Results 61 to 70 of about 61,487 (261)

Reliable Multiservice Delivery in Fog-Enabled VANETs: Integrated Misbehavior Detection and Tolerance

IEEE Access, 2019
Vehicular ad hoc networks (VANETs) in which vehicles act as the mobile nodes provide a wide variety of services, such as audio and video surveillance. However, such networks suffer from an important problem of service delivery reliability as the network ...
Xiaomei Zhang, Chen Lyu, Zhicai Shi, Dongmei Li, Neal N. Xiong, Chi-Hung Chi   +5 more
doaj   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Distributed Reliable and Efficient Transmission Task Assignment for WSNs

Sensors, 2019
Task assignment is a crucial problem in wireless sensor networks (WSNs) that may affect the completion quality of sensing tasks. From the perspective of global optimization, a transmission-oriented reliable and energy-efficient task allocation (TRETA) is
Xiaojuan Zhu, Kuan-Ching Li, Jinwei Zhang, Shunxiang Zhang   +3 more
doaj   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

TQRAM: tolerable QoS-aware resource allocation modeling in IoT based on Petri-Net

Discover Applied Sciences
In Internet of Things (IoT), load-balancing helps enhance resources utilization through efficient and fair task allocations between computing resources. On the other hand, a lack of load balancing means that some resources are under-loaded or idle, while
Mohammad Rostami, Salman Goli-Bidgoli
doaj   +1 more source

Genome-wide association study of drought tolerance and biomass allocation in wheat.

PLoS ONE, 2019
Genome wide association studies (GWAS) are important in discerning the genetic architecture of complex traits such as biomass allocation for improving drought tolerance and carbon sequestration potential of wheat.
Isack Mathew, Hussein Shimelis, Admire Isaac Tichafa Shayanowako, Mark Laing, Vincent Chaplot   +4 more
doaj   +1 more source

Erhöhte Frosttoleranz und vorteilhafte Keimeigenschaften in europäischen Ambrosia artemisiifolia Populationen

Julius-Kühn-Archiv, 2014
Germination characteristics and frost tolerance of seedlings are crucial parameters for establishment and invasion success of plants. Within this study, we investigated germination characteristics of Ambrosia artemisiifolia L. populations from native and
Leiblein-Wild, Marion Carmen, Kaviani, Rana, Tackenberg, Oliver   +2 more
doaj   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source