Results 121 to 130 of about 445,386 (301)
Hayula: Indonesian Journal of Multidisciplinary Islamic StudiesDuring rampant issues of radicalism and religious fanaticism reported in various newspapers and social media, the presence of young people is needed to become agents of moderation and tolerance.
Irhas Sabililhaq
doaj +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Primate dominance hierarchies: A review of theories and terminological ambiguities
Bulletins et Mémoires de la Société d’Anthropologie de ParisUnderstanding the causes and consequences of dominance hierarchies is one of the main goals of studies on social evolution, primatology, and anthropology. Several theories have been proposed to explain dominance hierarchies in primates, each attracting a
César Rodríguez del Castillo +3 more
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"Insecticide Resistance /Susceptibility Monitoring in Anopheles pulcherrimus (Diptera: Culicidae) in Ghasreghand District, Sistan and Baluchistan Province, Iran" [PDF]
Iranian Journal of Public Health, 2002 Two organochlorine, one organophosphate, two carbamate and two pyrethroid insecticides have been studied for their comparative study against fieldcollected An.pulcherrimus. The trail was conducted in Ghasreghand district, Sistan and Baluchistan province,
AH Zahirnia +3 more
doaj
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
AntibioticsBackground/Objetives: Antimicrobial Resistance (AMR) is a multifaceted issue that the World Health Organization (WHO) identifies as one of the primary threats to global health for humans, animals, and the environment.
Aura Falco +5 more
doaj +1 more source