Results 71 to 80 of about 366,302 (314)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Screening of Common Bean (Phaseolus vulgaris L) Germplasm for Drought Stress [PDF]
Journal of Stress Physiology & Biochemistry, 2023 Common bean is a species having high nutritional composition. Drought response in plants is complex phenomenon relating interactions between structure, functions and development of the plant. The Improvement of drought resistant for common bean has major
Priya S., Franklin C. Jose
doaj
Development of Tolerance and Gross Tolerance by Mephobarbital.
Experimental Biology and Medicine, 1952 Summary(1) Repeated daily intravenous injections of mephobarbital produces tolerance in experimental animals (rabbits). (2) The development of tolerance to mephobarbital also produces cross tolerance to butabarbital sodium.
M I, GLUCKMAN, C M, GRUBER
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
BMC Plant BiologyBackground Soil salinization severely affects plant growth and development and has become one of the important abiotic stresses limiting crop growth. To improve soybean yield in saline soils, it is important to understand how soybean responds to salt ...
Wenkang Huang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Dilemma Diagnoser Approach and its Application to the Fault-Tolerant Control of Planetary Exploration Rovers [PDF]
, 2013 Most of the fault-tolerant control strategies found in the literature assume conclusive diagnosis, i.e. the current fault mode of the plant is well-known. Although, speculative diagnosis can be a more realistic approach while noise corrupted measurements
Schäfer, Bernd / Robotik und Mechatronik +1 more
core
Acta Universitatis Sapientiae: Agriculture and Environment, 2019 Two field trials were carried out at the Teaching and Research Farm of the University of Ilorin in the 2012 and 2014 planting seasons to find out the effeciency of Trichoderma harzianum as a bio-control agent in controlling root-knot nematode ...
Izuogu N. B., Baba H. S., Winjobi E. O.
doaj +1 more source
Screening of Trichoderma strains tolerant to benzimidazole
浙江大学学报. 农业与生命科学版, 2004 The screening of isolates and the assay of biocontrol mechanisms of Trichoderma were studied systematically in laboratory and greenhouse in vivo. The proteins tolerant to benzimidazole in Trichoderma strains were purified, and their physical and chemical
LIU Kai-qi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source