Results 61 to 70 of about 14,100 (247)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Toleration and the Law

open access: yes, 2020
The merits, drawbacks and paradoxes of toleration have been studied extensively in political theory. By contrast, we know comparatively little about the salience of toleration to the law.
SMET, Stijn, Stijn Smet
core   +1 more source

ОСОБЕННОСТИ ФОРМИРОВАНИЯ МЕЖНАЦИОНАЛЬНЫХ ОТНОШЕНИЙ В УСЛОВИЯХ ВЫСШЕГО УЧЕБНОГО ЗАВЕДЕНИЯ

open access: yesНаучно-педагогическое обозрение, 2018
Раскрываются некоторые особенности формирования межнациональных отношений в условиях поликультурного пространства высшего учебного заведения. Проанализированы современные научные подходы к проблеме межнациональных и межэтнических отношений в обществе и ...
Тихонова Елена Александровна
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Toleration and Liberty of Conscience [PDF]

open access: yes, 2021
This chapter examines some central features to liberal conceptions of toleration and liberty of conscience. The first section briefly examines conceptions of toleration and liberty of conscience in the traditions of Locke, Rawls, and Mill.
Mahoney, Jon
core   +2 more sources

Diptych of human dignity and toleration [PDF]

open access: yesNBP: Nauka, bezbednost, policija, 2016
Human dignity and toleration are two extremely important social and legal values. Their existence is evidence of the civilization and cultural development of human societies. For this reason, they should be carefully fostered in them because it has to do
Mitrović Dragan M.
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

On toleration in social work [PDF]

open access: yes, 2017
Toleration is one of many responses towards diversity and difference. With the growing diversity, the theme of toleration has often taken centre stage in discussions of multiculturalism and social pluralism.
Lee, J-S ; https://orcid.org/, Besch, TM
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

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