Results 71 to 80 of about 14,100 (247)
Marvell Studies, 2018 You could be excused for thinking that rather than an Englishman, Andrew Marvell might better have been born a Dutchman in the republic’s golden age – an era of religious toleration and commercial ascendance, of fiscal accountability and civic ...
Steven Zwicker
doaj +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A Far Cry from Pluralistic Individualism: Enlightenment Toleration Revisited
ReligionsIn order to highlight the unprecedented character of Enlightenment toleration theories and their decisive role in the intellectual history of modern freedoms, these theories are often depicted as principled, based on individual rights, and aimed at ...
Juan Pablo Domínguez
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Soldiers and ‘respect’ in complex conflicts: an Afghan case
Etikk i Praksis: Nordic Journal of Applied Ethics, 2017 This paper discusses the meaning of ‘respect’ in complex conflicts and aims to be a contribution to thinking about ethics in war along with the Just War tradition. The point of departure is the increased focus on soldiers as moral decision-makers in war,
Cornelia Vikan
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Contemporary Liberalism and Toleration [PDF]
, 2015 Liberalism, historically, is closely associated with increased toleration, so it is unsurprising that a variety of contemporary authors (Hampton, Kukathas, Barry, Ten) consider toleration to be “the substantive heart of liberalism” (Hampton 1989, 802 ...
Cohen, Andrew Jason
core +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Unwanted yet Unavoidable Implementation of Religious Tolerance in Early Modern Transylvania
Central Europe, 2021 While most of early modern Europe was plunged into confessional strife, the central European principality of Transylvania managed to survive the period with no inter-confessional warfare.
Koloman Marschik
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source