Results 71 to 80 of about 72,239 (358)

The City as an Arena for the Expression of Multiple Identities in the Age of Globalisation and Migration [PDF]

open access: yes, 2003
This paper discusses the concept of toleration as it has been manifested in modern society through two contrasting processes - the prevalence of group identity, and the prevalence of identity defined according to citizenship and individual rights ...
Crane, Kristine
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Far Cry from Pluralistic Individualism: Enlightenment Toleration Revisited

open access: yesReligions
In order to highlight the unprecedented character of Enlightenment toleration theories and their decisive role in the intellectual history of modern freedoms, these theories are often depicted as principled, based on individual rights, and aimed at ...
Juan Pablo Domínguez
doaj   +1 more source

Delimitation of the ‘Public’ and Freedom of Conscience: Catholics’ Survival Tactics in Legal Discourses in Utrecht, 1630-1659

open access: yesEarly Modern Low Countries, 2019
This article aims to clarify Catholics’ survival tactics in discourses by analysing legal proceedings against them in the city of Utrecht from 1630 until 1659. This period saw a tendency towards Reformed confessionalisation, as is apparent from the rise
Genji Yasuhira
doaj   +1 more source

Tolerance, Mıgratıon And Hybrıd Identities: Normative Reasoning Of Intercultural Dialogue In A Blurring Structure [PDF]

open access: yes, 2016
The aim of this study is to proof the argument – i.e. ‘there are significant linkages amongst tolerance, hybrid identities and migration.’ These linkages can be comprehended by means of conceptualising extensions of hybrid identities in aggregate trans ...
Aliu, Armando   +3 more
core  

Forgiveness and Reconciliation [PDF]

open access: yes, 2017
Forgiveness and reconciliation are central to moral life; after all, everyone will be wronged by others and will then face the dual decisions of whether to forgive and whether to reconcile. It is therefore important that we have a clear analysis of each,
Emerick, Barrett
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Néhány lelkigondozói szempont a türelem fogalmi megközelítéséhez

open access: yesStudia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica, 2019
Some Pastoral Aspects about Approach of Toleration’s Concept. Toleration has many concepts. One of these concepts can be one of pastoral care. Why do we need this?
Szilárd SÁNDOR
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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