Results 91 to 100 of about 11,008 (309)
Philosophy of Toleration [PDF]
, 2009 The article deals with the origins and development of the issue of toleration; it refers to its most prominent moments and practical demonstrations in the history of Europe.
Novotný, Zdeněk
core +1 more source
A Far Cry from Pluralistic Individualism: Enlightenment Toleration Revisited
ReligionsIn order to highlight the unprecedented character of Enlightenment toleration theories and their decisive role in the intellectual history of modern freedoms, these theories are often depicted as principled, based on individual rights, and aimed at ...
Juan Pablo Domínguez
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Marvell Studies, 2018 You could be excused for thinking that rather than an Englishman, Andrew Marvell might better have been born a Dutchman in the republic’s golden age – an era of religious toleration and commercial ascendance, of fiscal accountability and civic ...
Steven Zwicker
doaj +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Soldiers and ‘respect’ in complex conflicts: an Afghan case
Etikk i Praksis: Nordic Journal of Applied Ethics, 2017 This paper discusses the meaning of ‘respect’ in complex conflicts and aims to be a contribution to thinking about ethics in war along with the Just War tradition. The point of departure is the increased focus on soldiers as moral decision-makers in war,
Cornelia Vikan
doaj +1 more source
'To tolerate or not to tolerate?'
, 2022 Many Western European countries have seen strong debates about minority rights and practices such as the founding of religious schools or the wearing of religious symbols in public institutions. In these increasingly diverse societies, tolerance of one another’s practices and beliefs has often been put forward as an indispensable ingredient for ...
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source