Results 101 to 110 of about 14,603 (295)

Becoming Begrudgingly Tolerant

open access: yesCentral Europe, 2021
The concept of religious tolerance and toleration has been the subject of much scholarly discussion for centuries. In the wake of the Reformation, however, it became a much more practical concept, with Europeans living next door to people perceived as ...
Andrew Wood-Martin
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Immanuel Kant on toleration

open access: yes, 2018
This thesis provides an account of Kant’s views on toleration, derived from the exegesis of relevant sections of his corpus. It begins by systematically surveying all direct examples of toleration-language in Kant’s works, and analysing these with a view
Andrew McEwen Bain (12311834)
core   +1 more source

Holism, Inconsistency Toleration and Inconsistencies between Theory and Observation

open access: yesHumana.Mente: Journal of Philosophical Studies, 2018
It has recently been argued by Davey (2014) that inconsistency is never tolerated in science, but only discretely isolated. But when talking about inconsistencies in science, not much attention has been paid to the inconsistencies between theory and ...
María del Rosario Martínez-Ordaz
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Irony and Toleration: Lessons from the Travels of Mendes Pinto

open access: yesRUDN Journal of World History, 2009
Rebecca Catz argues that Fernao Mendes Pinto's «Peregrination», a sprawling account of travels in the East first published in 1614, is a «plea for toleration». Richard Rorty says that irony is a good mode for postmodern intellectual life.
J C Laursen
doaj  

In search of the social: Rethinking toleration, remembering hospitality

open access: yesCogent Arts & Humanities, 2015
This article puts forward a historical and philosophical critique of the concept of toleration that questions it as an ultimate achievement and instead interrogates its limitations and seeks ways in which it may point to its own supercession in more ...
Evy Varsamopoulou
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Justice et tolérance. La question du hobbisme du jeune Locke [PDF]

open access: yesMeta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2015
This article treats about the influence of Hobbes on the early writings of John Locke, Two Tracts on Government (1660 and 1662). These Tracts don’t have a particular importance in understanding Locke’s work, but they are important for understanding the ...
Gabriela Ratulea
doaj  

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