Results 111 to 120 of about 11,008 (309)
Religion, Reason, and Toleration [PDF]
, 2017 This chapter compares two Enlightenment theories of religious toleration: the theories of Pierre Bayle and Immanuel Kant. Both Bayle and Kant argued for an autonomous conception of morality as the ground of reciprocal and universal toleration, but they ...
Rainer Forst
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Early Modern Low Countries, 2019 This article aims to clarify Catholics’ survival tactics in discourses by analysing legal proceedings against them in the city of Utrecht from 1630 until 1659. This period saw a tendency towards Reformed confessionalisation, as is apparent from the rise
Genji Yasuhira
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Ecclesiology, Ecumenism, and Toleration [PDF]
, 2017 This chapter discusses Leibniz’s conception of the Christian church, his life-long ecumenical efforts, and his stance toward religious toleration. Leibniz regarded the main Christian denominations as particular churches constituting the only one truly ...
Maria Rosa Antognazza +1 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
ProfilMacIntyre’s ‘liberal’ view of the state’s toleration of hate speech may seem surprising given his radical rejection of liberalism. It appears liberal because MacIntyre agrees with some classical liberal conclusions, as formulated by Locke, concerning the
Marian Kuna
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Toleration as Asymmetric Recognition [PDF]
, 2019 In this paper I argue for a conception of toleration as asymmetric recognition. I start from an analysis of the concept of toleration, and of the reasons that underpin such an act; then, the distinction between toleration and recognition is highlighted ...
Macioce, F. (Fabio)
core