Results 121 to 130 of about 11,008 (309)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Holism, Inconsistency Toleration and Inconsistencies between Theory and Observation
Humana.Mente: Journal of Philosophical Studies, 2018 It has recently been argued by Davey (2014) that inconsistency is never tolerated in science, but only discretely isolated. But when talking about inconsistencies in science, not much attention has been paid to the inconsistencies between theory and ...
María del Rosario Martínez-Ordaz
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Irony and Toleration: Lessons from the Travels of Mendes Pinto
RUDN Journal of World History, 2009 Rebecca Catz argues that Fernao Mendes Pinto's «Peregrination», a sprawling account of travels in the East first published in 1614, is a «plea for toleration». Richard Rorty says that irony is a good mode for postmodern intellectual life.
J C Laursen
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Morality Of Toleration: Towards a Realist Account of Political Toleration [PDF]
, 2015 Western societies today are marked by a broad liberal consensus in favour of toleration. Yet, some philosophers have charged that toleration as a liberal ideal is incoherent. Some have argued that toleration is incompatible with liberal political orders.
Khameh, Armin
core +1 more source
Mémoires de la Saint-Barthélemy
Etudes EpistémèAt the start of the twenty-first century, 450 years after the massacre of St Bartholomew’s Day, the remembrance of this tragic ‘bloody night’ has re-emerged with force in the collective memory and in the public sphere. This revival is not just the result
Tatiana Debbagi Baranova +2 more
doaj +1 more source