Results 81 to 90 of about 14,100 (247)

Néhány lelkigondozói szempont a türelem fogalmi megközelítéséhez

open access: yesStudia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica, 2019
Some Pastoral Aspects about Approach of Toleration’s Concept. Toleration has many concepts. One of these concepts can be one of pastoral care. Why do we need this?
Szilárd SÁNDOR
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Constantinian Toleration

open access: yes, 2018
Recent secular theorists of toleration have turned to Christian thought as a resource to overcome problems faced by secular-liberal accounts of toleration.
Vincent Lloyd
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Immanuel Kant on toleration

open access: yes, 2018
This thesis provides an account of Kant’s views on toleration, derived from the exegesis of relevant sections of his corpus. It begins by systematically surveying all direct examples of toleration-language in Kant’s works, and analysing these with a view
Andrew McEwen Bain (12311834)
core   +1 more source

Bayle\u27s Theory of Toleration [PDF]

open access: yes, 2011
This paper gives an overview of Pierre Bayle’s theory of toleration and derives a normative principle of toleration from it that is meant to compete with other normative principles of toleration such as the Harm ...
Fischer, Benjamin Eliazar
core   +1 more source

Modus vivendi beyond toleration

open access: yes, 2021
This chapter will focus on the relationship between toleration and modus vivendi. The overall aim is to defend an idea of modus vivendi as a strategy for the political inclusion of people who are not tolerant, without betraying the fundamentals of ...
Sala R
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

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