Results 141 to 150 of about 457 (170)
Some of the next articles are maybe not open access.
Journal of Labelled Compounds and Radiopharmaceuticals, 1999
Tolperisone (2) has been tritiated to 50 Ci/mmol specific activity in order to use this compound in the study of muscle relaxant binding. Of the two reaction pathways investigated, hydrogenolytic exchange of aromatic bromine is favored over hydrogenation of a double bond. Copyright © 1999 John Wiley & Sons, Ltd.
Axel Dietrich, Gregor Fels
exaly +2 more sources
Tolperisone (2) has been tritiated to 50 Ci/mmol specific activity in order to use this compound in the study of muscle relaxant binding. Of the two reaction pathways investigated, hydrogenolytic exchange of aromatic bromine is favored over hydrogenation of a double bond. Copyright © 1999 John Wiley & Sons, Ltd.
Axel Dietrich, Gregor Fels
exaly +2 more sources
Considerable interindividual variation in the pharmacokinetics of tolperisone HCl
Int. Journal of Clinical Pharmacology and Therapeutics, 2007 The aim of this study was to determine the pharmacokinetic profiles of oral tolperisone hydrochloride in healthy volunteers.After the oral administration of tolperisone hydrochloride, the plasma concentrations of tolperisone were measured in 15 healthy male Korean volunteers.
J W, Bae +5 more
openaire +3 more sources
Simultaneous determination of tolperisone and lidocaine by high performance liquid chromatography
Journal of Pharmaceutical and Biomedical Analysis, 2001A reversed phase high performance liquid chromatographic (RP-HPLC) method for the simultaneous determination of tolperisone (TP) and lidocaine (LD) has been developed. The drugs were separated on a column (4.60 x 250 mm(2)) Spherisorb ODS (5 microm) using 5.5% triethylamine in 70/30 v/v acetonitrile/water as mobile phase 0.7 ml min(-1)and UV detection ...
Saisunee Liawruangrath +1 more
exaly +3 more sources
Expert Opinion on Therapeutic Targets, 2023 Drug repurposing is an attractive strategy for extending the arsenal of oncology therapies. Tolperisone is an old centrally acting muscle relaxant used for treatment of chronic pain conditions.
Zhiwei Yang, Yubo Wang, Meichen Wang
exaly +2 more sources
Synthesis, resolution and absolute configuration of a tolperisone metabolite
Tetrahedron: Asymmetry, 2001 Abstract 1-(4′-Hydroxymethyl-phenyl)-2-methyl-3-(piperidine-1-yl)-propane-1-one M2, a metabolite of tolperisone, was synthesised in a solvent-free Mannich reaction. The optical resolution was carried out by diastereoisomeric salt formation and separation, for which three resolving agents ((2R,3R)-O,O′-dibenzoyl tartaric acid, (2R,3R)-O,O′-di-p ...
József Bálint +5 more
openaire +2 more sources
Fatal tolperisone poisoning: Autopsy and toxicology findings in three suicide cases
Forensic Science International, 2012 Tolperisone (Mydocalm) is a centrally acting muscle relaxant with few sedative side effects that is used for the treatment of chronic pain conditions. We describe three cases of suicidal tolperisone poisoning in three healthy young subjects in the years ...
Frank Sporkert, Patrice Mangin
exaly +2 more sources
High performance thin layer chromatographic determination of tolperisone hydrochloride
Journal of Pharmaceutical and Biomedical Analysis, 1999Saisunee Liawruangrath +1 more
exaly +3 more sources
Synthesis and resolution of a Tolperisone metabolite
Tetrahedron: Asymmetry, 2000Abstract The synthesis and resolution of a Tolperisone metabolite ((3′-hydroxy-4′-methylphenyl)-2-methyl-3-(piperidine-1-yl)-1-propane-1-one, M1 ) is described. Racemic M1 was subjected to resolution by the enantiomers of camphor-10-sulfonic acid. Absolute configuration was determined by X-ray diffraction analysis.
József Bálint +4 more
openaire +1 more source
Simultaneous micellar LC determination of lidocaine and tolperisone
Journal of Pharmaceutical and Biomedical Analysis, 2003A micellar liquid chromatography (MLC) procedure was developed for the simultaneous separation and determination of lidocaine hydrochloride (LD HCl) and tolperisone hydrochloride (TP HCl) using a short-column C18 (12.5 mm x 4.6 mm, 5 microm), sodium dodecyl sulfate (SDS) with a small amount of isopropanol, and diode array detector.
Napaporn, Youngvises +2 more
openaire +2 more sources