Pregabalin–Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats [PDF]
Pharmaceuticals, 2023 The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel agents or combination-based analgesic therapies are needed.
David A Karadi +2 more
exaly +5 more sources
Efficacy and safety of tolperisone versus baclofen among Chinese patients with spasticity associated with spinal cord injury: a non-randomized retrospective study [PDF]
Brazilian Journal of Medical and Biological Research, 2021 There are many medications available to treat spasticity, but the tolerability of medications is the main issue for choosing the best treatment. The objectives of this study were to compare the efficacy and adverse effects of tolperisone compared to ...
Mingheng Li +4 more
doaj +3 more sources
NMR study of the inclusion complexes of β-cyclodextrin with diphenhydramine, clonidine and tolperisone [PDF]
SN Applied Sciences, 2022 Forming complexes with β-cyclodextrin can enhance stability, dissolution rate, solubility, and bioavailability of an active pharmaceutical ingredient. In this study, the inclusion behavior between β-cyclodextrin (β-CD) and diphenhydramine, clonidine, and
Symbat Zhumakova +2 more
exaly +3 more sources
Sustainable Removal of Tolperisone from Waters by Application of Photocatalysis, Nanotechnology, and Chemometrics: Quantification, Environmental Toxicity, and Degradation Optimization [PDF]
Nanomaterials, 2022 Environmental pollution is an emerging global issue. Heterogenous photocatalytic degradation, which belongs to the advanced oxidation processes, is a promising sustainable technique for the removal of harmful pollutants (e.g., pharmaceuticals) from ...
Szabolcs Bognár +5 more
doaj +3 more sources
The associations between central serous chorioretinopathy and muscle relaxants: A case–control study [PDF]
Taiwan Journal of Ophthalmology, 2022 PURPOSE: To evaluate the role of muscle-relaxants as risk factors for the development of central serous chorioretinopathy (CSC) - the second most common retinopathy in our settings; despite multiple risk factors seen in our patients, 21% were initially ...
Manish Jain +6 more
doaj +4 more sources
The Acute Antiallodynic Effect of Tolperisone in Rat Neuropathic Pain and Evaluation of Its Mechanism of Action [PDF]
International Journal of Molecular Sciences, 2022 Current treatment approaches to manage neuropathic pain have a slow onset and their use is largely hampered by side-effects, thus there is a significant need for finding new medications.
David A Karadi +2 more
exaly +3 more sources
Centrally Acting Skeletal Muscle Relaxants Sharing Molecular Targets with Drugs for Neuropathic Pain Management [PDF]
Brain SciencesTreatment of neuropathic pain (NP) remains a challenge in clinical practice because the current treatment approaches produce satisfactory pain alleviation in only 30% of patients.
Judit Mária Kirchlechner-Farkas +10 more
doaj +2 more sources
Tolperisone in the treatment of acute and chronic nonspecific back pain
Неврология, нейропсихиатрия, психосоматика, 2020 Nonspecific back pain (NBP) is one of the most common reasons to see a neurologist or therapist. Acute (<4 weeks' duration), subacute (4 to 12 weeks), and chronic (>12 weeks) NBPs are recognized.
V. A. Golovacheva +3 more
doaj +3 more sources
Неврология, нейропсихиатрия, психосоматика, 2019 Objective: to comparatively evaluate the clinical efficiency of cervicocranialgia therapy with dexketoprofen (flamadex) and tolperisone (calmyrex), as well as with their combination. Patients and methods. The investigation enrolled 90 patients aged 30–60
M. N. Dadasheva +2 more
doaj +3 more sources