Results 51 to 60 of about 4,432 (285)

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

open access: yesAdvanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong   +12 more
wiley   +1 more source

Dual‐Modular Hydrogel Microparticles with Precision‐Modulation of Inflammatory Microenvironment Dictate Full‐Thickness Cartilage Regeneration for Osteoarthritis Repair

open access: yesAdvanced Science, EarlyView.
Cartilage injury is a prominent pathological hallmark of osteoarthritis. In this study, we developed a two‐modular hydrogel microparticle system wherein HMP‐A effectively targets the damaged area, while HMP‐B forms an efficient connection with HMP‐A on the cartilage surface.
Xinye Chen   +5 more
wiley   +1 more source

Engineered Anti‐Senescence Trachea With Post‐Transplanted Regenerative Homeostasis

open access: yesAdvanced Science, EarlyView.
Bioengineered trachea undergoes post‐transplanted senescence, which is found in this study for the first time. Hebe‐ET is designed with dual anti‐senescence strategies: fiber‐film scaffold in cartilage rings for close‐packed cell interaction, and quercetin‐loaded fibrous rings for immune modulation.
Ziyin Pan   +14 more
wiley   +1 more source

Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long‐Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells

open access: yesAdvanced Science, EarlyView.
This study identifies akermanite among six bioceramics and reveals its ability to enhance Schwann cell's proliferation, migration, and secretion. When combined with silk sericin, the composite conduit synergistically enhances Schwann cell‐mediated regenerative processes.
Qiangfei Su   +10 more
wiley   +1 more source

II. Transformation of aniline into toluidine [PDF]

open access: yesProceedings of the Royal Society of London, 1873
Whilst engaged with the experiments described in the previous paper, I have made some observations which I may be allowed briefly to mention to the Society, since the coming autumnal vacation will suspend work for a time. In reviewing the experience collected as to the action of high temperatures upon trimethylated phenylammonium iodide, the question ...
openaire   +2 more sources

Monocyclic aromatic amines as potential human carcinogens: old is new again [PDF]

open access: yes, 2009
Alkylanilines are a group of chemicals whose ubiquitous presence in the environment is a result of the multitude of sources from which they originate.
Kim, Min Young   +4 more
core   +2 more sources

Establishment and evaluation of a novel rat model of the fourth ventricle hemorrhage

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this study, a novel rat model of fourth ventricle hemorrhage was established via autologous blood injection through the foramen of Magendie. Anesthetized rats were positioned in a stereotaxic apparatus with their heads tilted downward at an angle of approximately 20° relative to the vertical axis.
Chuhua Fu   +8 more
wiley   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere   +4 more
wiley   +1 more source

Microwave assisted synthesis of indoles: Madelung's Reaction [PDF]

open access: yes, 2008
The 12th International Electronic Conference on Synthetic Organic Chemistry session Symposium on Microwave Assisted SynthesisMicrowave assisted Madelung indole synthesis was achieved under solvent-free conditions using potassium tert-butoxide as baseWe ...
Crecente Campo, José   +4 more
core   +1 more source

Pratiques phytosanitaires paysannes dans les savanes d'Afrique centrale [PDF]

open access: yes, 2009
International audienceAvec une production de plus de 300 000 tonnes, la culture cotonnière joue un rôle moteur dans l'économie sous-régionale de l'Afrique centrale.
Acheleke, Joseph   +5 more
core   +1 more source

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