Clinically Advanced Warty Invasive Squamous Cell Carcinoma of the Cervix with p16 Overexpression—Case Study and Literature Review [PDF]
Background and Clinical Significance: Warty (condylomatous) squamous cell carcinoma (SCC) of the uterine cervix is a rare papillary variant of SCC, usually associated with good prognosis. Case Presentation: We report the clinical case of a postmenopausal
Laura-Andra Petrică +4 more
doaj +2 more sources
Interplay Between Immune Microenvironment CD8+ Tumor-Infiltrating Lymphocytes and PDL-1 Expression as Prognostic Markers in Invasive Cervical Squamous Cell Carcinoma [PDF]
Background: Cervical cancer remains a major cause of cancer-related morbidity and mortality worldwide, with limited therapeutic options for advanced disease.
Laura-Andra Petrică +10 more
doaj +2 more sources
Ethanol-Induced Dysbiosis and Systemic Impact: A Meta-Analytical Synthesis of Human and Animal Research [PDF]
Background: Chronic ethanol consumption is a major global health concern traditionally associated with liver disease. Ethanol disrupts gut microbial communities, compromises intestinal barrier function, and contributes to hepatic, metabolic, and ...
Luana Alexandrescu +13 more
doaj +2 more sources
Twisted Troubles: A Rare Case of Intestinal Obstruction Due to Endometriosis and a Review of the Literature [PDF]
Background and Objectives: Intestinal endometriosis is an exceptionally rare cause of intestinal obstruction. This case report and literature review aim to highlight the clinical presentation, diagnostic challenges, and surgical management of this ...
Ionut Eduard Iordache +8 more
doaj +2 more sources
Spontaneous Coronary Artery Dissection Involving the Left Main with Extension to Left Anterior Descending Artery and Left Circumflex Artery: Diagnostic and Management Challenges [PDF]
Spontaneous coronary artery dissection is a rare cause of unstable angina, myocardial infarction, and sudden cardiac death, particularly among young women and individuals without conventional atherosclerotic risk factors. We present the case of a 43-year-
Constantin Andrei Rusali +4 more
doaj +2 more sources
Spontaneous Coronary Artery Dissection Unveiled: Pathophysiology, Imaging, and Evolving Management Strategies [PDF]
Spontaneous coronary artery dissection (SCAD) is an increasingly recognized, non-atherosclerotic cause of acute coronary syndrome (ACS), particularly in younger women.
Constantin Andrei Rusali +3 more
doaj +2 more sources
Smart Microbiomes: How AI Is Revolutionizing Personalized Medicine [PDF]
Background: Recent studies have shown that gut microbiota have important roles in different human diseases. There has been an ever-increasing application of high-throughput technologies for the characterization of microbial ecosystems.
Luana Alexandrescu +13 more
doaj +2 more sources
Intestinal Insights: The Gut Microbiome’s Role in Atherosclerotic Disease: A Narrative Review [PDF]
Recent advances have highlighted the gut microbiota as a significant contributor to the development and progression of atherosclerosis, which is an inflammatory cardiovascular disease (CVD) characterized by plaque buildup within arterial walls.
Luana Alexandrescu +14 more
doaj +2 more sources
Left Atrial Strain—Current Review of Clinical Applications [PDF]
Left atrial strain has gained significant attention in recent years due to its potential to provide valuable insights into the function and mechanics of the left atrium.
Constantin Andrei Rusali +3 more
doaj +2 more sources
Basing the Decisions Regarding the Optimal Variant of the Maintenance Policy Based on the Criterion of Economic Costs [PDF]
By maintenance we mean a set of technical-organizational activities, whose purpose is to ensure maximum performance for the good considered (equipment, building, installation, etc.) Based on these considerations, the aim of this work is to make the ...
Paul Bocănete +2 more
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