Results 81 to 90 of about 227,718 (311)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Acta Dermato-Venereologica, 2020 The amount of training needed to correctly interpret optical coherence tomography scans of the skin is undefined. The aim of this study was to illustrate how cumulative sum charts can be used to determine how many optical coherence tomography scans ...
Eva van Loo +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites [PDF]
, 2012 Background: Demodex mites are involved in different skin diseases and are commonly detected by skin scrape tests or superficial biopsies. A new high-definition optical coherence tomography (HD-OCT) with high lateral and axial resolution in a horizontal ...
Sattler, E. +4 more
core +1 more source
Recent developments in multimodality fluorescence imaging probes
Acta Pharmaceutica Sinica B, 2018 Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging (OFI) probe
Jianhong Zhao +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Journal of Biomedical Optics, 1996 This paper gives an introduction to optical coherence tomography (OCT), explains its basic principles, and discusses the information content of OCT images. Various interferometric techniques used in OCT are reviewed and a short survey of results obtained so far in different fields of application and possible future developments are presented.
openaire +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Comparative signal-to-noise analysis of fibre-optic based optical coherence tomography systems
, 2005 Several optical coherence tomography ( OCT) systems are proposed using optical. fibre components and based around Fizeau sensing interferometers. The theoretical signal- to- noise ratio ( SNR) is calculated for each of the proposed configurations ...
Beddows, R. +3 more
core +1 more source
BMC Cardiovascular DisordersBackground Polyvascular disease (PVD), defined as atherosclerosis involving ≥ 2 vascular beds, confers poor clinical outcome but lacks early noninvasive predictors.
Minghao Liu +20 more
doaj +1 more source