Results 111 to 120 of about 1,757,096 (355)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

On the fundamental tone of minimal submanifolds with controlled extrinsic curvature [PDF]

open access: yes, 2013
The aim of this paper is to obtain the fundamental tone for minimal submanifolds of the Euclidean or hyperbolic space under certain restrictions on the extrinsic curvature.
Gimeno, Vicent
core   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Òun, ohun, ohùn

open access: yesNordic Journal of African Studies, 2019
This article reports the results of an experimental study of the realisation of /h/ in Yoruba. The aim was to determine whether the 1974 orthography convention requiring that òun “3rd Sg” be written without “h” while ohun “thing” be written with the ...
Kolawole Adeniyi
doaj   +1 more source

Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group.

open access: yesJournal of the American Medical Association (JAMA), 1998
CONTEXT Nonpharmacologic interventions are frequently recommended for treatment of hypertension in the elderly, but there is a paucity of evidence from randomized controlled trials in support of this recommendation.
P. Whelton   +11 more
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

Influences of Implementing the Learning Organisation on Companies’ Financial and Non-Financial Performances [PDF]

open access: yes
The learning organisation (LO) concept as one of the numerous management tools available has been significantly gaining in popularity around the globe.
Tone Cesnovar
core  

Dynamic club formation with coordination [PDF]

open access: yes, 2002
We present a dynamic model of jurisdiction formation in a society of identical people. The process is described by a Markov chain that is defined by myopic optimization on the part of the players.
Arnold, Tone, Wooders, Myrna Holtz
core   +1 more source

P300- like event related potential amplitude in rats is a correlate of conditioned reinforcement [PDF]

open access: yes, 2012
We have developed a methodology for recording a robust P300 event related potential (ERP) in rats. In these experiments a contingency shaped model of the human “oddball’ paradigm was employed in which rats were shaped to press a lever for
Steven Faux, William D. Klipec
core   +2 more sources

Handling Tone in Two-Level Morphology

open access: yesNordic Journal of African Studies, 2004
The problem of handling tone in morphological parsing has not yet been widely addressed. The morphological parsers are typically developed for languages without contrastive tonal systems, and the application of such parsers need to be adapted to handle ...
Lotta Harjula
doaj   +1 more source

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