Results 21 to 30 of about 18,998 (242)

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

open access: yesAdvanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang   +11 more
wiley   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

open access: yesAdvanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen   +9 more
wiley   +1 more source

Spatial Transcriptional Dynamics of CD74⁺ B Cells in Tertiary Lymphoid Structures Drive Immune Evolution in Penile Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
In penile squamous cell carcinoma, a higher tertiary lymphoid structure score is associated with improved survival. This is mediated by CD74⁺ B cells, which exhibit early developmental plasticity and the ability to differentiate into plasma cells. Functioning as a molecular switch, these cells activate naive T cells via HLA‐DRA–CD4 interaction, thereby
Ting Xue   +16 more
wiley   +1 more source

The Italian Dubbing of Dialects, Accents and Slang in the British Dark Comedy Drama Misfits [PDF]

open access: yes, 2016
Although they are far from reflecting real interaction stricto sensu, TV series try to recreate a sort of idealised community. In order to do this, the language they use is based on those communicative patterns that are deemed prototypical for a given ...
Dore, Margherita
core  

Trisomy 5p: Long Recognized, Rarely Published‐ Three New Cases and Review of the Literature

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Complete trisomy 5p is a rare chromosomal disorder caused by a duplication of the short arm of chromosome 5. Current data suggest that complete trisomy 5p presents as a distinct clinical syndrome including but not limited to seizures, developmental delays, facial dysmorphisms, failure to thrive, and recurrent respiratory infections.
Gabriela J. Kim   +2 more
wiley   +1 more source

Spartan Daily, September 25, 2008 [PDF]

open access: yes, 2008
Volume 131, Issue 16https://scholarworks.sjsu.edu/spartandaily/10500/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

open access: yesAnnals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang   +10 more
wiley   +1 more source

Spartan Daily, October 20, 1942 [PDF]

open access: yes, 1942
Volume 31, Issue 14https://scholarworks.sjsu.edu/spartandaily/3494/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +1 more source

Early life functional transitions impact craniofacial morphology in osteogenesis imperfecta

open access: yesThe Anatomical Record, EarlyView.
Abstract Early life behaviors have a profound role in shaping adult craniofacial morphology. During early life, all mammals undergo the dynamic transition from suckling to mastication, a period coinciding with rapid cranial biomineralization. Osteogenesis imperfecta (OI), a genetic disorder that impacts the production of type I collagen, disrupts ...
Courtney A. Miller   +2 more
wiley   +1 more source

Our World, Our Futures: A dialogic approach to environmental literacy and global citizenship education in primary schools in the Maldives and England

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Environmental literacy and global citizenship education (GCE) are necessary to the development of a fairer, more peaceful and more sustainable world, but teachers frequently lack practical examples of their implementation in the classroom.
Claire Lee   +2 more
wiley   +1 more source

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