Results 51 to 60 of about 27,635 (246)

Safety and Efficacy Findings From a Phase Ib/II Study of ASP‐1929 Photoimmunotherapy With Pembrolizumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background ASP‐1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing. Methods This phase Ib/II open‐label study evaluated ASP‐1929 photoimmunotherapy plus pembrolizumab in patients with recurrent/metastatic HNSCC (≥ 1 accessible lesion, PD‐L1 ...
David M. Cognetti, Joseph M. Curry, Jennifer Johnson, Michael Kwon, Shirley Y. Su, Francisco Civantos, Coral Olazagasti, Joseph Valentino, Susanne M. Arnold, R. Bryan Bell, Michael K. Gibson, Kyle Mannion, Kathryn M. Van Abel, Katharine A. Price, Haiying Dong, Amy H. Thorne, Toshiaki Suzuki, Ann M. Gillenwater   +17 more
wiley   +1 more source

Neck Dissection Reduces Risk of Recurrence in Early‐Stage Oral Tongue Cancer

Head &Neck, EarlyView.
ABSTRACT Background Patterns of failure in early‐stage oral tongue squamous cell carcinoma (OTSCC) managed with surgery alone remain understudied. Methods Retrospective cohort study from 2000 to 2022 at a single tertiary care center evaluated pT1‐T2N0 OTSCC patients who underwent partial glossectomy with or without elective neck dissection (END ...
Jaclyn Lee, Tan Ding, Mae Wimbiscus, Dandan Liu, Melanie D. Hicks, Alexander J. Langerman, Robert J. Sinard, Kyle Mannion, Sarah L. Rohde, Eben L. Rosenthal, Michael C. Topf   +10 more
wiley   +1 more source

Survival Impact and Risk Factors of Cervical Lymph Node Metastasis in Maxillary Gingival Squamous Cell Carcinoma: A Retrospective Study of 81 Patients

Head &Neck, EarlyView.
ABSTRACT Background This study aimed to investigate the survival impact and predictive factors of cervical lymph node metastasis (CLNM) in patients with maxillary gingival squamous cell carcinoma (MGSCC). Methods This retrospective study included 81 patients with MGSCC who underwent radical surgery from 2008 to 2018.
Takeshi Kuroshima, Naoya Kinoshita, Naoto Nishii, Yu Oikawa, Takuma Kugimoto, Hideaki Hirai, Hirofumi Tomioka, Yasuyuki Michi, Hiroyuki Harada   +8 more
wiley   +1 more source

A case report: Diagnosis and treatment of idiopathic hypertrophic pachymeningitis

Ibrain, Volume 11, Issue 1, Page 112-116, Spring 2025.
We reported a case of idiopathic hypertrophic dura meningitis diagnosed in our hospital. The patient repeatedly suffered from headaches, followed by blurred vision in the right eye. During this period, multiple sclerosis was considered for diagnosis, and it improved after hormone treatment.
Zhong Luo, Piao Cao, Jing‐Qing Xu, Rong Yan, Jian Wang, Tao Liang, Ya Chen, Zu‐Cai Xu   +7 more
wiley   +1 more source

Evaluating ChatGPT's recommendations for systematic treatment decisions in recurrent or metastatic head and neck squamous cell carcinoma: Perspectives from experts and junior doctors

International Journal of Cancer, EarlyView.
What's New? While artificial intelligence (AI) can potentially support clinical decision‐making in recurrent head and neck squamous cell carcinoma (HNSCC), its reliability and accuracy require extensive investigation. Here, the performance of ChatGPT‐4 as a decision‐support tool for staging and treatment planning in HNSCC was assessed. The tool was 83%
Danfang Yan, Lihong Wang, Liming Huang, Kejia Cheng, Yu Huang, Yangyang Bao, Xin Yin, Mengye He, Huiyong Zhu, Senxiang Yan   +9 more
wiley   +1 more source

Toxicities in long‐term survivors of head and neck cancer—A multi‐national cross‐sectional analysis

International Journal of Cancer, EarlyView.
What's New? Cancer treatments frequently have toxic effects on the body, and these toxicities may cause long‐term health issues. Here, the authors report the results of a large, international study to evaluate long‐term toxicities of treatment for head and neck cancer (HNC).
Katherine J. Taylor, Cecilie D. Amdal, Kristin Bjordal, Guro L. Astrup, Bente B. Herlofson, Fréderic Duprez, Ricardo R. Gama, Alexandre Jacinto, Eva Hammerlid, Melissa Scricciolo, Femke Jansen, Irma M. Verdonck‐de Leeuw, Giuseppe Fanetti, Orlando Guntinas‐Lichius, Johanna Inhestern, Tatiana Dragan, Alexander Fabian, Andreas Boehm, Ulrike Wöhner, Naomi Kiyota, Maximilian Krüger, Pierluigi Bonomo, Monica Pinto, Sandra Nuyts, Joaquim Castro Silva, Carmen Stromberger, Pol Specenier, Francesco Tramacere, Ayman Bushnak, Pietro Perotti, Michaela Plath, Alberto Paderno, Noa Stempler, Maria Kouri, Vincent Grégoire, Silke Tribius, Susanne Singer, on behalf of the EORTC Quality of Life Group and the EORTC Head and Neck Group   +37 more
wiley   +1 more source

Biological evaluation of a glucose‐based boron carrier as a potential agent for boron neutron capture therapy

International Journal of Cancer, EarlyView.
What's New? Boron neutron capture therapy (BNCT) is a targeted form of radiation therapy designed to selectively destroy cancer cells. BNCT is not widely used, however, owing in part to challenges involving selective boron delivery to tumors. The present study evaluated the potential of a novel glucoconjugate, 6‐O‐(o‐carboranylmethyl)‐d‐glucopyranose ...
Surachet Imlimthan, Katayun Bahrami, Henna Pehkonen, Alessia Centanni, Ahmed B. Montaser, Arina Värä, Jelena Matović, Heidi Liljenbäck, Tatsiana Auchynnikava, Kristiina M. Huttunen, Anne Roivainen, Anu J. Airaksinen, Filip S. Ekholm, Outi Monni, Jarkko Rautio, Mirkka Sarparanta   +15 more
wiley   +1 more source

Age and tumour presentations differ between HPV type 16 positive and other high‐risk HPV type‐positive oropharyngeal squamous cell carcinomas in a Swedish cohort of 2000–2022

International Journal of Cancer, EarlyView.
What's New? The incidence of oropharyngeal squamous cell carcinoma (OPSCC) associated with human papillomavirus (HPV) is rising dramatically. Among patterns linked to this increase is the occurrence of high‐risk (HR)‐HPV types in specific age groups. Here, the authors investigated relationships between age and HR‐HPV‐positive OPSCCs, including HPV16 ...
Anders Näsman, Madeleine Birgersson, Tobias Näsman, Evelina Jörtsö, Mark Zupancic, Rusana Bark, Linda Marklund, Tina Dalianis   +7 more
wiley   +1 more source

Body height and the excess cancer risk in men

International Journal of Cancer, EarlyView.
What's New? In cancers that affect both sexes, men usually have a higher risk than women. While this is often attributed to behavioral factors, such as exposure to environmental carcinogens, there may be an intrinsic biological mechanism involved. Tall stature has been associated with increased cancer risk.
Cecilia Radkiewicz, Gustaf Edgren, Arvid Sjölander, Emelie Benyi, Mats Lambe, Paul W. Dickman, Lars Sävendahl   +6 more
wiley   +1 more source

The microbiome in cancer

iMeta, EarlyView.
This comprehensive review elucidates the transformative role of the human microbiome in cancer biology, revealing innovative mechanistic insights into the intricate tumor–microbe interactions across diverse organ systems. This work highlights the clinical and translational value of novel microbiome‐based biomarkers for early detection, prognosis, and ...
Anqi Lin, Minying Xiong, Aimin Jiang, Lihaoyun Huang, Hank Z. H. Wong, Suyin Feng, Chunyan Zhang, Yu Li, Li Chen, Hao Chi, Pengpeng Zhang, Bicheng Ye, Hengguo Zhang, Nan Zhang, Lingxuan Zhu, Weiming Mou, Junyi Shen, Kailai Li, Wentao Xu, Haoxuan Ying, Cangang Zhang, Dongqiang Zeng, Jindong Xie, Xinpei Deng, Qi Wang, Jianying Xu, Wenjie Shi, Chang Qi, Chunrun Qu, Xufeng Huang, András Hajdu, Chaoqun Li, Changmin Peng, Xuanye Cao, Guangsheng Pei, Lin Zhang, Yujia Huo, Jiabao Xu, Antonino Glaviano, Attila Gábor Szöllősi, Sicheng Bian, Zhengrui Li, Hailin Tang, Bufu Tang, Zaoqu Liu, Jian Zhang, Kai Miao, Quan Cheng, Ting Wei, Shuofeng Yuan, Peng Luo   +50 more
wiley   +1 more source