Results 101 to 110 of about 10,823,317 (311)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Case Studies in Thermal EngineeringThis paper presents an evaluation of the thermal performance of a circular tube with louvered V-winglet inserts (LVWs) under turbulent flow conditions.
Anuwat Saenpong +3 more
doaj +1 more source
Tribology Online, 2006 Micro-Traction-Drive is made by modified angular contact ball bearings. It is developed for the purpose of transmitting high torque with small drive size.
Isamu Shiotsu +3 more
doaj +1 more source
Towards a change process planning tool [PDF]
, 2003 The relationship between a product and its design process is generally complex and not fully understood. When modifying a product, industry still rarely considers the implementation process and its consequences for other design activities in the company,
Clarkson, P. J., Eckert, C. M., Eger, T.
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
, 2012 Methodological approaches for comparing metabolic theory predictions to empirical data fall into two general categories: 1) determining if the general functional form of a relationship predicted by the theory is valid; and 2) determining whether the observed values of the parameters match the specific quantitative predictions made by the theory.
White, Ethan P. +3 more
openaire +2 more sources
Top Ten Google Apps Tool Tips [PDF]
, 2016 There\u27s at least ten Google Drive, Docs, Forms, and Sheets items I couldn\u27t live without and not one of them is an Add-on. While this isn\u27t a hands-on workshop, you may follow along on your own laptop as I demonstrate uses for Quick Sum, Explore,
Durkacs, Suzanne
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source