Results 231 to 240 of about 947,545 (301)

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Effectiveness and cost-effectiveness of a peer-delivered, relational, harm reduction intervention to improve mental health, quality of life, and related outcomes, for people experiencing homelessness and substance use problems: protocol for the 'SHARPS' cluster randomised controlled trial. [PDF]

Trials
Parkes T, Carver H, Boyd J, Cotton S, Breeman S, Cooper D, Forrest M, Foster R, Hawthorn J, Hunt K, Kilonzo M, Matheson C, Maxwell M, Mercer SW, Pauly B, Scotland G, Steele W, Sumnall H, Wallace J, Macaulay L, MacLennan G.   +20 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Enterprise-wide simultaneous deployment of ambient scribe technology: lessons learned from an academic health system. [PDF]

J Am Med Inform Assoc
Wright AP, Nall CK, Franklin JJH, Horst SN, Kumah-Crystal YA, Wright AT, Mize DE.   +6 more
europepmc   +1 more source

Building an initial programme theory to explain how and why on-the-day surgery cancellations occur and how they might be reduced. [PDF]

BMC Health Serv Res
Samarasinghe BSW, Millar R, Exworthy M, Aunger J.   +3 more
europepmc   +1 more source

Commentary: Leveraging big data in health care and public health for AI driven talent development in rural areas. [PDF]

Front Public Health
Sujithra R, Bini Marin V, Sreya B.
europepmc   +1 more source