Results 121 to 130 of about 9,278,986 (351)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Cutting tool condition monitoring of the turning process using artificial intelligence
, 2012 This thesis relates to the application of Artificial Intelligence to tool wear monitoring. The main objective is to develop an intelligent condition monitoring system able to detect when a cutting tool is worn out.
Silva, R. G.
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
NT-proBNP as a risk stratification tool for the management of acute decompensated heart failure [PDF]
, 2018 The burden of heart failure (HF) remains high, with worrisome morbidity and mortality rates for patients hospitalized for acute decompensated heart failure (ADHF). The natriuretic peptides, BNP and the inactive N-terminal fragment of its precursor proBNP
Salah, Khibar, Salah, K.
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
CETGI : an assessment tool for global concurrent engineering : executive summary [PDF]
Industrial globalisation and the increased complexity of products promote new product development (NPD) by distributed teams. These teams facilitate the transfer of designs to manufacturing facilities, the adaptation of products to local markets and ...
Balbontin-Posadas, Alejandro
core
Delayed failure of software components using stochastic testing [PDF]
, 2012 The present research investigates the delayed failure of software components and addresses the problem that the conventional approach to software testing is unlikely to reveal this type of failure. Delayed failure is defined as a failure that occurs some
Gardiner, Jeremy
core
COFUN: A new tool for evaluating containment failure frequency and uncertainty
Nuclear Engineering and TechnologyThe feature of the COntainment Failure probability and Uncertainty aNalysis program (COFUN) is the quantification of the containment state. The probability factors used in probabilistic safety assessment (PSA) and the resulting outputs contain ...
Dohyun Lim, Byeongmun Ahn, Moosung Jae
doaj +1 more source