Results 81 to 90 of about 9,278,986 (351)

Comprehensive Complexity-Based Failure Modeling for Maintainability and Serviceability [PDF]

, 2009
Organised by: Cranfield UniversityFailures are the primary triggers for repair and maintenance actions. A clear definition of failure events is important in order to improve maintainability and serviceability.
ElMaraghy, H. A., Meselhy, K. T., ElMaraghy, W. H.   +2 more
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Nursing Insights: A Descriptive Correlational Study Linking Self-Efficacy, Self-Care Behaviors, and Quality of Life in Heart Failure Care [PDF]

Egyptian Journal of Health Care
Background: Heart failure (HF) is a life-threatening condition affecting over 64 million people globally, leading to significant morbidity, mortality, and healthcare costs.
Marwa Abdelhamid Mohammed Mahmoud, Mohamed Abd El-Rahman Elsaied Elhoty, Sabah Nazeh Mohamed Elderiny   +2 more
doaj   +1 more source

Cardiac Hormones as Diagnostic Tools in Heart Failure [PDF]

Endocrine Reviews, 2003
In patients with heart failure, plasma levels of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and the N-terminal fragments of their prohormones (N-ANP and N-BNP) are elevated, because the cardiac hormonal system is activated by increased wall stretch due to increased volume and pressure overload.
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Investigating causal factors of road damage: a case study

MATEC Web of Conferences, 2019
High rainfall leads to flood vulnerability and potentially leads to the failure of road pavement which affects the economic loss for the people. However, such road pavement failures need to be studied more deeply to be able to distinguish whether the ...
Hatmoko Jati Utomo Dwi, Setiadji Bagus Hario, Wibowo Mohammad Agung   +2 more
doaj   +1 more source

Tool Wear and Life Span Variations in Cold Forming Operations and Their Implications in Microforming

Technologies, 2016
The current paper aims to review tooling life span, failure modes and models in cold microforming processes. As there is nearly no information available on tool-life for microforming the starting point was conventional cold forming.
Anders E. W. Jarfors, Sylvie J. Castagne, Atsushi Danno, Xinping Zhang   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Automated spontaneous breathing trial performance tool is associated with improved outcomes following pediatric cardiac surgery: A single-center retrospective study from Alabama, USA

Journal of Pediatric Critical Care
Background: Extubation failure is associated with significant morbidity, including prolonged time on ventilator and longer hospital length of stay (LOS). Extubation readiness is assessed with a variety of tools. Using algorithmic analysis, we developed a
Matthew G. Clark, Santiago Borasino, Hayden J. Zaccagni, Shannon Payne, Justin Raper, Jeremy Loberger, Kristal M. Hock, Ahmed Asfari   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Implementation of a Risk Stratification Tool for Hospitalized Heart Failure Patients to Improve Utilization of Palliative Care Consultations

, 2018
Purpose: The purpose of this study was to explore the incidence of palliative care consultations for hospitalized heart failure patients through implementation of a validated risk stratification tool.|Background: Heart failure is a multifaceted ...
Hansen, LeeAnn
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