Results 41 to 50 of about 210,779 (247)

Looked at Life from Both Sides Now

open access: yesLife, 2014
As the molecular top–down causality emerging through comparative genomics is combined with the bottom–up dynamic chemical networks of biochemistry, the molecular symbiotic relationships driving growth of the tree of life becomes strikingly apparent ...
Jillian E. Smith   +3 more
doaj   +1 more source

Processing of fMRI-related anxiety and bi-directional information flow between prefrontal cortex and brain stem

open access: yesScientific Reports, 2021
Brain–heart synchronization is fundamental for emotional-well-being and brain–heart desynchronization is characteristic for anxiety disorders including specific phobias.
Gert Pfurtscheller   +6 more
doaj   +1 more source

An Aristotelian Account of Evolution and the Contemporary Philosophy of Biology [PDF]

open access: yes, 2014
The anti-reductionist character of the recent philosophy of biology and the dynamic development of the science of emergent properties prove that the time is ripe to reintroduce the thought of Aristotle, the first advocate of a “top-down” approach in life-
Tabaczek, Mariusz
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Optimal control methods for simulating the perception of causality in young infants [PDF]

open access: yes, 1999
There is a growing debate among developmental theorists concerning the perception of causality in young infants. Some theorists advocate a top-down view, e.g., that infants reason about causal events on the basis of intuitive physical principles. Others
Barto, Andrew, Schlesinger, Matthew
core  

DramaQA: Character-Centered Video Story Understanding with Hierarchical QA

open access: yes, 2020
Despite recent progress on computer vision and natural language processing, developing video understanding intelligence is still hard to achieve due to the intrinsic difficulty of story in video. Moreover, there is not a theoretical metric for evaluating
Choi, Seongho   +7 more
core   +2 more sources

New Experiments for Spontaneous Vortex Formation in Josephson Tunnel Junctions [PDF]

open access: yes, 2006
It has been argued by Zurek and Kibble that the likelihood of producing defects in a continuous phase transition depends in a characteristic way on the quench rate.
A. Barone   +10 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

DIVINE AGENCY AND THE PRINCIPLE OF THE CONSERVATION OF ENERGY

open access: yesZygon, 2009
Many contemporary thinkers seeking to integrate theistic belief and scientific thought reject what they regard as two extremes. They disavow deism in which God is understood simply to uphold the existence of the physical universe, and they exclude any ...
doaj   +2 more sources

The Role of the Key Components of Renewable Energy (Combustible Renewables and Waste) in the Context of CO2 Emissions and Economic Growth of Selected Countries in Europe

open access: yesEnergies, 2021
In the case of developing countries, it is not clear which crisis management tools will ensure sustainable development in a sustainable and environmentally friendly way, as well as reducing CO2 emissions in addition to ensuring GDP growth.
Shahjahan Ali   +2 more
doaj   +1 more source

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