Results 61 to 70 of about 2,966,724 (259)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Manual sobre voluntariado con personas con síndrome de Down

open access: yes, 2020
El presente manual tiene como propósito ofrecer información básica a las personas que de forma solidaria y altruista desean realizar tareas de voluntariado con personas con síndrome de Down dentro de las entidades que conforman Down ...
Down España
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

El síndrome de Down hoy: dirigido a familias y profesionales

open access: yes, 2020
Con esta guía Down España quiere aclarar los interrogantes que puedan surgir a los padres o futuros padres de niños con síndrome de Down y a sus familiares.
Down España
core  

La atención médica al adulto con síndrome de Down [PDF]

open access: yes, 2012
Recomendaciones sobre hábitos saludables, especialistas a los que es imprescindible visitar, vacunaciones, la etapa del envejecimiento, cuestiones como el alzhéimer o la salud mental.
Down España
core  

From ESP to CLIL using the Schema Theory

open access: yesRevista de Lenguas para Fines Específicos, 2013
This paper explains the use of the Schema Theory in planning and preparing a Physiology lesson in a CLIL tertiary context in a Spanish university. The adopted combination of methods used in applying the theory is transferable to any context and subject ...
Nashwa Nashaat Sobhy   +2 more
doaj  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

Distinguishing causality principles [PDF]

open access: yes, 2012
We distinguish two sub-types of each of the two causality principles formulated in connection with the Common Cause Principle in Henson (2005) and raise and investigate the problem of logical relations among the resulting four causality principles. Based
Rédei, Miklós, San Pedro, Iñaki
core   +1 more source

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