Results 71 to 80 of about 2,966,724 (259)

Problems of Causality of Micro and Macro Levels of Object: “Top-down” and “Bottom-up” (Ontological Aspect)

open access: yesRUDN Journal of Philosophy, 2015
The authors pay their attention to the scientific problems in the natural sciences centered around the concept of causality. In the situation of crisis the importance of causal links of objects especially increases.
K K Vasilyeva, A N Lochkina
doaj  

The Life and Works of a Bottom‐Up Thinker

open access: yesZygon, 2000
A brief account is given of the author's life as a physicist and then a priest. The twin foundations of the author's theological endeavors have been a respect for traditional Christian thinking, though not exempting it from revision where this is needed,
doaj   +2 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Campus Network Design And Implementation Using Top Down Approach: A Case Study Tarumanagara University [PDF]

open access: yes, 2012
Tarumanagara University already has a computer network infrastructure to support various activities both administrative and academic. Infrastructure that was built has been covering all areas of the building and the floor.
Bagus, Mulyawan
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Top-down organizational change in an Australian Government agency

open access: yes, 2008
Purpose – The purpose of this paper is to assist public sector organizations to carry out better change management strategies and thus achieve better change processes and also to provide a critique of top-down change strategies, especially when employed ...
Ryan, Neal   +7 more
core   +1 more source

The Circularity of the Embodied Mind

open access: yesFrontiers in Psychology, 2020
From an embodied and enactive point of view, the mind–body problem has been reformulated as the relation between the lived or subject body on the one hand and the physiological or object body on the other (“body–body problem”). The aim of the paper is to
Thomas Fuchs
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

La investigación sobre el cerebro en el síndrome de Down [PDF]

open access: yes, 2012
Todos sabemos que el síndrome de Down es una alteración genética producida por la existencia de una copia extra de genes situada en el cromosoma 21. Desde hace tiempo se conocen las alteraciones morfológicas del cerebro en las personas con síndrome de ...
Martínez Pérez, Salvador
core  

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

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