Results 201 to 210 of about 9,334,973 (302)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Effective Pruning for Top-k Feature Search on the Basis of SHAP Values. [PDF]
IEEE AccessChabrier L +3 more
europepmc +1 more source
, 2011 본 발명은 대량의 원소로 구성된 집합에서 집합의 크기에 선형적으로 비례하는 시간 동안 가장 큰(또는 작은) 키 값을 가지는 k개의 원소(Top-k 결과)만을 정렬된 순서로 찾기 위한 알고리즘에 관한 것으로, 본 발명에 따르면, 크기가 k인 최소(또는 최대) 힙 구조에 Top-k 결과의 후보 데이터를 유지하는 알고리즘을 통하여 한 번의 데이터 스캔으로 Top-k 결과를 구할 수 있는 방법이 제공된다. 즉, 본 발명에 따르면, Top-k 결과를 찾기
황규영
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Any-k: Anytime Top-k Tree Pattern Retrieval in Labeled Graphs. [PDF]
Proc Int World Wide Web Conf, 2018 Yang X +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A Fast and Efficient Algorithm for Mining Top-k Nodes in Complex Networks. [PDF]
Sci Rep, 2017 Liu D, Jing Y, Zhao J, Wang W, Song G.
europepmc +1 more source