A Study of the Top and Middle Managers knowledge and Attitude on the Feasibility of Applying Total Quality Management in Hospitals of Tehran University of Medical Science in 2009 [PDF]
پیاورد سلامت, 2010 Background and Aim: Managers today work in a dynamic environment. Their role in creating quality is essential. Today paying attention to the quality of goods and services is the first Paiority in heath care organizations which is in with contact ...
A Fayazbakhsh, S Safarani, A Ahangar
doaj +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Discursive resources, the identities of top managers and the long term sustainability of their organizations [PDF]
, 2011 This thesis represents an attempt to understand the dynamics of the identity work in the context of the challenges top managers have to address. Managers’ discursive resources influence what they notice and also the interpretation of what is noticed ...
Aguiar, M
core
, 2020 This study explores the role and facilitating actions of top managers in response to the digital transformation. Building on 27 in-depth interviews with top managers and close associates from large German firms, we find that top managers respond to the ...
Dauth, Tobias +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A study of top managers' capability
, 2010 碩士本研究是以國內五大民營電信業者高階主管為研究對象，探討電信業高階主管與企業組織的供需間，高階主管應擁有的條件與特質是組織最需要的？及什麼樣的組織對高階主管才具有加入的吸引力？故本研究以分析招募高階主管時應審視之條件、探討高階主管另覓職務時個人應備基本條件、提供人力仲介業者媒合高階主管人力供需時的參考暨提出吸引高階人才之組織特性為主要研究目的。本研究透過對國內五大民營電信業者高階主管的訪談，與本研究彙整的文獻探討進行比對，除依序列出重要順序外，研究結果發現與文獻探討所研究之特質相較，大致相符 ...
曾惠芬; Tseng, Hui-fen
core
How hospital top managers reason about the central leadership task of balancing quality of patient care, economy and professionals' engagement: an interview study. [PDF]
Leadersh Health Serv (Bradf Engl), 2022 Bååthe F +2 more
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source