Results 111 to 120 of about 2,599,225 (293)

Probing the flavour structure of dimension-6 EFT operators in multilepton final states in proton-proton collisions at s = 13 $$ \sqrt{s}=13 $$ TeV

open access: yesJournal of High Energy Physics
An analysis of the flavour structure of dimension-6 effective field theory (EFT) operators in multilepton final states is presented, focusing on the interactions of quarks with Z bosons.
The CMS collaboration   +2430 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Hadronic Top Quark Polarimetry with ParticleNet [PDF]

open access: yesPhysics Letters B
Precision studies for top quark physics are a cornerstone of the Large Hadron Collider program. Polarization, probed through decay kinematics, provides a unique tool to scrutinize the top quark across its various production modes and to explore potential
Zhongtian Dong   +4 more
semanticscholar   +1 more source

Measurement of the t t ¯ H $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ and tH production rates in the H → b b ¯ $$ \textrm{b}\overline{\textrm{b}} $$ decay channel using proton-proton collision data at s $$ \sqrt{s} $$ = 13 TeV

open access: yesJournal of High Energy Physics
An analysis of the production of a Higgs boson (H) in association with a top quark-antiquark pair ( t t ¯ H $$ \textrm{t}\overline{\textrm{t}}\textrm{H} $$ ) or a single top quark (tH) is presented.
The CMS collaboration   +2384 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Inclusive and differential cross section measurements of t t ¯ b b ¯ $$ \textrm{t}\overline{\textrm{t}}\textrm{b}\overline{\textrm{b}} $$ production in the lepton+jets channel at s $$ \sqrt{s} $$ = 13 TeV

open access: yesJournal of High Energy Physics
Measurements of inclusive and normalized differential cross sections of the associated production of top quark-antiquark and bottom quark-antiquark pairs, t t ¯ b b ¯ $$ \textrm{t}\overline{\textrm{t}}\textrm{b}\overline{\textrm{b}} $$ , are presented ...
The CMS collaboration   +2362 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Top Quark Physics

open access: yes, 2000
111 pages, Latex, to appear in the Report of the ``1999 CERN Workshop on SM physics (and more) at the LHC'', M.Beneke, I.Efthymiopoulos, M.L.Mangano, J.Womersley (conveners)
Beneke, M.   +77 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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