Results 111 to 120 of about 2,120 (275)

Nasal Gouty Tophus [PDF]

Ear, Nose & Throat Journal, 2016
Pei-Hsun, Liao, Kuo-Ping, Chang
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Path Analysis Identifies Receptor Activator of Nuclear Factor-κB Ligand, Osteoprotegerin, and Sclerostin as Potential Mediators of the Tophus-bone Erosion Relationship in Gout

, 2016
Objective. To determine the relationship between tophus, erosion and bone remodeling factors in gout. Methods. Computed tomography bone erosion and circulating bone factors were measured in adults with tophaceous gout.
Gamble, Gregory, Doyle, Anthony, Reid, Ian, Dalbeth, Nicola, Aati, O, Roger, M, McQueen, Fiona, Cornish, Jillian, Horne, Anne, Callon, Karen, Chhana, Ashika   +10 more
core  

Mechanisms of bone erosion in gout; a quantitative analysis of plain radiography and computed tomography.

, 2008
Objective: The underlying basis of bone erosion in gout remains speculative. The aim of this study was to understand the mechanisms of bone erosion in gout using non-invasive imaging techniques.
Clark, B, Gamble, Gregory, Doyle, Anthony, Dalbeth, Nicola, McQueen, Fiona, Sheehan, T, Gregory, Kate   +6 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Gouty tophus in the vocal fold: A rare case report

Tophi, a common manifestation of gout, are rarely observed in the larynx. We report a case of a 39-year-old male presenting with hoarseness and mild dysphonia. Electronic laryngoscopy revealed a submucosal lesion on the right true vocal fold.
Jianli Zhang, Jingjia Li, Zijian He, Weixiong Chen   +3 more
core   +1 more source

Atypical musculoskeletal manifestations of gout in hyperuricemia patients

Open Access Rheumatology: Research and Reviews, 2019
Muhammad Sakti, Muhammad Andry Usman, Jansen Lee, Michael Benjamin, Qariah Maulidiah Department of Orthopaedic and Traumatology, Hasanuddin University Teaching Hospital, Makassar, Indonesia Abstract: Deposition of tophus is a common feature in chronic ...
Sakti M, Usman MA, Lee J, Benjamin M, Maulidiah Q   +4 more
doaj  

Gouty Tophus at the Lateral Canthus [PDF]

Archives of Ophthalmology, 2003
William R, Morris, James C, Fleming
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Case Report of a Rare Dorsal Nasal Gouty Tophus Presenting With a “Hump Nose” Deformity

This report describes an exceptionally rare case of a dorsal nasal gouty tophus presenting as a “hump nose” deformity—an atypical location for tophaceous gout that has been scarcely documented in the literature.
Dingjun Zha, Xiao-dong Chen, Hongli Fan, Gang Liu, Genglong Shi   +4 more
core   +1 more source