Results 1 to 10 of about 9,207 (164)

Integration of single-cell cis-expression quantitative trait locus and Mendelian randomization analyses identifies a Treg-specific gene for precision therapy in rheumatoid arthritis, gonarthrosis, and gouty arthritis [PDF]

open access: yesJournal of International Medical Research
Objective Arthritis, including rheumatoid arthritis, gonarthrosis, and gouty arthritis, poses a substantial public health challenge. Regulatory T cells are critical for immune homeostasis, and their dysfunction contributes to arthritis pathogenesis ...
Tianqi Ren   +6 more
doaj   +2 more sources

Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

open access: yesJournal of Inflammation Research
Cantao Li,* Chenxi Wu,* Fenfen Li, Wenjing Xu, Xiaoxi Zhang, Yan Huang, Daozong Xia School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to ...
Fenfen Li, Daozong Xia, Xiaoxi Zhang
exaly   +2 more sources

Older age and diclofenac are associated with increased risk of upper gastrointestinal bleeding in gout patients [PDF]

open access: yesPeerJ, 2021
Background Gouty arthritis is a disease of global burden in which defective metabolism of uric acid causes arthritis. Gouty arthritis or medications used for its treatment may lead to uric acid-associated complications such as upper gastrointestinal ...
Wan Syamimee Wan Ghazali   +4 more
doaj   +2 more sources

Vertebrae Destruction with Cauda Equina Syndrome Secondary to Spinal Gouty Arthritis: A Case Report [PDF]

open access: yesMalaysian Orthopaedic Journal, 2020
Gouty arthritis commonly affects peripheral joints and is associated with hyperuricaemia. Spinal manifestations of gouty arthritis are not common, and majority of published articles worldwide were case reports.
Thuraikumar K, Wan KL, Ong KL, Lim SW
doaj   +1 more source

Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis

open access: yesJournal of Innate Immunity, 2023
PR domain-containing 1 with zinc finger domain (PRDM1) has been reported as a promoter of inflammation, which is a critical process involved in the pathogenesis of acute gouty arthritis.
Qingsong Zhao   +6 more
doaj   +1 more source

Neutrophil autophagy induced by monosodium urate crystals facilitates neutrophil extracellular traps formation and inflammation remission in gouty arthritis

open access: yesFrontiers in Endocrinology, 2023
Neutrophil extracellular traps (NETs) are composed of chromatin filaments coated with granular and cytosolic proteins, which contribute to the pathogenesis and progression of immune-related diseases.
Shanshan Huang   +5 more
doaj   +1 more source

Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies

open access: yesJournal of Translational Medicine, 2023
Background Acute gouty arthritis is inflammatory joint arthritis. Gouty arthritis (GA) involves multiple pathological processes. Deposition of joints by monosodium urate (MSU) crystals has been shown to play a critical role in the injury process.
Weili Fu, Minghao Ge, Jian Li
doaj   +1 more source

Lagotis brachystachya maxim attenuates chronic alcoholic liver injury combined with gouty arthritis in rats via its anti-inflammatory activity

open access: yesFrontiers in Pharmacology, 2022
Lagotis brachystachya Maxim, a common herb in Tibetan medicine, is mainly used to treat pneumonia, hepatitis, yellow water disease (gouty arthritis). Since long-term heavy drinking is also a risk factor for gouty arthritis, the present study aimed to ...
Min-Xia Guo   +7 more
doaj   +1 more source

Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation

open access: yesArthritis Research & Therapy, 2023
Background Gouty arthritis is the most frequently diagnosed inflammatory arthritis worldwide. Dynamin-related protein 1 (Drp1), a regulator of mitochondrial fission, contributes to various inflammatory disorders via activating NLRP3 inflammasome. However,
Qingdong Wang, Hongbin Qiu
doaj   +1 more source

Comparison of MR Findings between Patients with Septic Arthritis and Acute Gouty Arthritis of the Knee

open access: yes대한영상의학회지, 2022
Purpose To compare the MR findings of septic and acute gouty arthritis of the knee joint. Materials and Methods This retrospective study included patients who underwent knee MRI for septic or gouty arthritis at our hospital between October 2012 and ...
Su Young Yun   +3 more
doaj   +1 more source

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