Results 81 to 90 of about 146,074 (263)
, 2020 This paper presents a new topic modelling framework inspired by game theoretic principles. It is formulated as a normal form game in which words are represented as players and topics as strategies that the players select. The strategies of each player are modelled with a probability distribution guided by a utility function that the players try to ...
openaire +3 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
ConTopic: Human-in-the-loop neural topic modeling with constraint loss for topic quality improvement
Visual InformaticsExisting neural topic models often produce semantically ambiguous or low-quality topics, limiting their effectiveness in real-world applications. To address this, we propose ConTopic, a human-in-the-loop framework that integrates user-defined “must-link”
Qiuchen Fan, Yue Shen, Jie Li
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Research Community Mining via Generalized Topic Modeling [PDF]
Mehran University Research Journal of Engineering and Technology, 2012 Mining research community on the basis of hidden relationships present between its entities is important from academic recommendation point of view. Previous approaches discovered research community by using network connectivity based distance measures
Ali Daud +2 more
doaj
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Automatic Seed Word Selection for Topic Modeling
IEEE AccessTopic modeling is widely used to uncover latent semantic topics from a corpus. However, topic models often struggle to identify minor topics due to their tendency to prioritize dominant patterns in the data. They are also hindered by polysemous words and
Dahyun Jeong +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source