Results 101 to 110 of about 3,873,151 (300)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
COMPARISON OF TOPIC MODELING METHODS FOR ANALYZING TWEETS ON COVID-19 VACCINE
, 2023 Twitter is a microblogging site and a popular social media platform for sharing thoughts on current world events. The dynamic of Twitter discussions makes it a valuable data source for mining people's opinions and emotions towards world events.
Khanjarinezhadjooneghani, Zeinab +1 more
core
ConTopic: Human-in-the-loop neural topic modeling with constraint loss for topic quality improvement
Visual InformaticsExisting neural topic models often produce semantically ambiguous or low-quality topics, limiting their effectiveness in real-world applications. To address this, we propose ConTopic, a human-in-the-loop framework that integrates user-defined “must-link”
Qiuchen Fan, Yue Shen, Jie Li
doaj +1 more source
, 2010 We introduce supervised latent Dirichlet allocation (sLDA), a statistical model of labelled documents. The model accommodates a variety of response types. We derive an approximate maximum-likelihood procedure for parameter estimation, which relies on variational methods to handle intractable posterior expectations.
David M. Blei, Jon D. McAuliffe
openaire +3 more sources
, 2020 This paper presents a new topic modelling framework inspired by game theoretic principles. It is formulated as a normal form game in which words are represented as players and topics as strategies that the players select. The strategies of each player are modelled with a probability distribution guided by a utility function that the players try to ...
openaire +3 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source