Results 111 to 120 of about 637,325 (290)

Homogenization of some degenerate pseudoparabolic variational inequalities

open access: yes, 2018
Multiscale analysis of a degenerate pseudoparabolic variational inequality, modelling the two-phase flow with dynamical capillary pressure in a perforated domain, is the main topic of this work.
Ptashnyk, Mariya
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Linear State Models for Volatility Estimation and Prediction [PDF]

open access: yes, 2006
This report covers the important topic of stochastic volatility modelling with an emphasis on linear state models. The approach taken focuses on comparing models based on their ability to fit the data and their forecasting performance.
Date, P, Hawkes, R
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

LDAExplore: Visualizing Topic Models Generated Using Latent Dirichlet Allocation [PDF]

open access: yes, 2015
We present LDAExplore, a tool to visualize topic distributions in a given document corpus that are generated using Topic Modeling methods. Latent Dirichlet Allocation (LDA) is one of the basic methods that is predominantly used to generate topics. One of
Brantley, Kiante   +3 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Ideologies in Geospatial Futurism: A Computational and Critical Discourse Inquiry Into the ArcGIS and ESRI-Blogs

open access: yesMedia and Communication
Geographic information systems (GIS) are ubiquitous building blocks of geosurveillance environments embedded in everyday social practices. This article builds on the literature on geomedia, the criticisms of GIS, and communicative spaces, to delve into ...
Helena Atteneder   +1 more
doaj   +1 more source

Kernel Topic Models

open access: yes, 2011
Latent Dirichlet Allocation models discrete data as a mixture of discrete distributions, using Dirichlet beliefs over the mixture weights. We study a variation of this concept, in which the documents' mixture weight beliefs are replaced with squashed Gaussian distributions.
Hennig, P.   +3 more
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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