Results 101 to 110 of about 637,325 (290)
Visualizing Topic Uncertainty in Topic Modelling
, 2023 Word clouds became a standard tool for presenting results of natural language processing methods such as topic modelling. They exhibit most important words, where word size is often chosen proportional to the relevance of words within a topic. In the latent Dirichlet allocation (LDA) model, word clouds are graphical presentations of a vector of weights
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Regional Control of Probabilistic Cellular Automata
, 2018 Probabilistic Cellular Automata are extended stochastic systems, widely used for modelling phenomena in many disciplines. The possibility of controlling their behaviour is therefore an important topic.
Bagnoli, Franco +3 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Identifying Student Discussion in Computer-Mediated Problem Solving Chat [PDF]
, 2017 The COMPS project employs computer chat for students working in small groups solving classroom problems. This summer’s project aims to build computer classifiers that could effectively “look over the shoulders” of the students while working, to ...
Arndt, Lindsey K +2 more
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Predicting Good Configurations for GitHub and Stack Overflow Topic Models
, 2019 Software repositories contain large amounts of textual data, ranging from source code comments and issue descriptions to questions, answers, and comments on Stack Overflow.
Treude, Christoph, Wagner, Markus
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Potential of Blogs for Higher Degree Supervision. [PDF]
, 2009 This article discusses the potential of the use of blog technology in supporting research students at the university, and encourages its wider use. Individual blogs open only to student and supervisors can focus and structure dialogue and discussion ...
Bigger, Stephen
core +1 more source