Results 161 to 170 of about 62,077 (260)

Dynamic suicide topic modelling: Deriving population-specific, psychosocial and time-sensitive suicide risk variables from Electronic Health Record psychotherapy notes. [PDF]

Clin Psychol Psychother, 2023
Levis M, Levy J, Dufort V, Russ CJ, Shiner B.   +4 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The quality and scope of health information on online drug platforms: a topic modelling and expert evaluation study of a Polish-language forum. [PDF]

Harm Reduct J
Siuda P, Matuszewski P.
europepmc   +1 more source

Dynamic Topic Modelling for Exploring the Scientific Literature on Coronavirus: An Unsupervised Labelling Technique

, 2023
Guillén-Pacho I, Badenes-Olmedo C, Corcho O.   +2 more
europepmc   +1 more source

Correction to: Guidelines: a structural topic modelling analysis of free-text data from 17,500 UK adults. [PDF]

BMC Public Health, 2022
Wright L, Paul E, Steptoe A, Fancourt D.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Age-dependent topic modelling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk

, 2022
Jiang X, McVean G, Price AL, Zhang M, Zhang Y, Inouye M, Holmes C.   +6 more
europepmc   +2 more sources

Scalable topic modelling decodes spatial tissue architecture for large-scale multiplexed imaging analysis. [PDF]

Nat Commun
Peng X, Smithy JW, Yosofvand M, Kostrzewa CE, Bleile M, Ehrich FD, Lee J, Postow MA, Callahan MK, Panageas KS, Shen R.   +10 more
europepmc   +1 more source

Using topic modelling for unsupervised annotation of electronic health records to identify an outbreak of disease in UK dogs. [PDF]

PLoS One, 2021
Noble PM, Appleton C, Radford AD, Nenadic G.   +3 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source