Results 31 to 40 of about 308,523 (269)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mechanisms and active components of Solanum nigrum in the amelioration of psoriatic lesions

Frontiers in Immunology
IntroductionPsoriasis is a prevalent chronic inflammatory skin disease in which pattern recognition receptors, particularly the NLRP3 inflammasome, are increasingly implicated in disease pathogenesis.
Ya Chen, Ya Chen, Tianyou Ma, Tianyou Ma, Congcong Zhu, Congcong Zhu, Zongguang Tai, Zongguang Tai, Huijun Pan, Huijun Pan, Zhongjian Chen, Zhongjian Chen, Quangang Zhu, Quangang Zhu   +13 more
doaj   +1 more source

Topical non-steroidal immunomodulators in dermatology

Indian Dermatology Online Journal, 2023
Immunological abnormality is the pathological basis of many dermatological disorders. Although steroids are the backbone of topical therapy in dermatology, the side effects are encountered quite frequently.
Priya P Kadu
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Interventions in cytokine signaling: novel horizons for psoriasis treatment

Frontiers in Immunology
Intricate interactions between immune cells and cytokines define psoriasis, a chronic inflammatory skin condition that is immunological-mediated. Cytokines, including interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, and ...
Lisha Li, Lisha Li, Lisha Li, Jun Liu, Jun Liu, Jiaye Lu, Jiaye Lu, Junchao Wu, Junchao Wu, Xinyue Zhang, Xinyue Zhang, Tianyou Ma, Tianyou Ma, Xiying Wu, Xiying Wu, Quangang Zhu, Quangang Zhu, Zhongjian Chen, Zhongjian Chen, Zongguang Tai, Zongguang Tai   +20 more
doaj   +1 more source

A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne

Frontiers in Medicine, 2022
IntroductionAcne can compromise facial esthetics and become a mental burden, especially when it occurs in puberty. Skincare cosmetics with anti-acne efficiency is more convenient than other treatment modalities, such as dietary supplements, in certain ...
Hongchang Cui, Chaoqun Guo, Qian Wang, Congrui Feng, Zhi Duan   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Topic essentials [PDF]

Proceedings of the 11th coference on Computational linguistics -, 1986
An overview of TOPIC is provided, a knowledge-based text information system for the analysis of German-language texts. TOPIC supplies text condensates (summaries) on variable degrees of generality and makes available facts acquired from the texts. The presentation focuses on the major methodological principles underlying the design of TOPIC: a frame ...
Udo Hahn, Ulrich Reimer
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source