Results 41 to 50 of about 642,884 (313)

A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne

Frontiers in Medicine, 2022
IntroductionAcne can compromise facial esthetics and become a mental burden, especially when it occurs in puberty. Skincare cosmetics with anti-acne efficiency is more convenient than other treatment modalities, such as dietary supplements, in certain ...
Hongchang Cui, Chaoqun Guo, Qian Wang, Congrui Feng, Zhi Duan   +4 more
doaj   +1 more source

Topical Word Embeddings

AAAI Conference on Artificial Intelligence, 2015
Most word embedding models typically represent each word using a single vector, which makes these models indiscriminative for ubiquitous homonymy and polysemy. In order to enhance discriminativeness, we employ latent topic models to assign topics for
Y. Liu, Zhiyuan Liu, Tat-Seng Chua, Maosong Sun   +3 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Topical non-steroidal immunomodulators in dermatology

Indian Dermatology Online Journal, 2023
Immunological abnormality is the pathological basis of many dermatological disorders. Although steroids are the backbone of topical therapy in dermatology, the side effects are encountered quite frequently.
Priya P Kadu
doaj   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Interventions in cytokine signaling: novel horizons for psoriasis treatment

Frontiers in Immunology
Intricate interactions between immune cells and cytokines define psoriasis, a chronic inflammatory skin condition that is immunological-mediated. Cytokines, including interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, and ...
Lisha Li, Lisha Li, Lisha Li, Jun Liu, Jun Liu, Jiaye Lu, Jiaye Lu, Junchao Wu, Junchao Wu, Xinyue Zhang, Xinyue Zhang, Tianyou Ma, Tianyou Ma, Xiying Wu, Xiying Wu, Quangang Zhu, Quangang Zhu, Zhongjian Chen, Zhongjian Chen, Zongguang Tai, Zongguang Tai   +20 more
doaj   +1 more source

Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews.

Cochrane Database of Systematic Reviews, 2017
BACKGROUND Topical analgesic drugs are used for a variety of painful conditions. Some are acute, typically strains or sprains, tendinopathy, or muscle aches. Others are chronic, typically osteoarthritis of hand or knee, or neuropathic pain.
S. Derry, P. Wiffen, Eija A Kalso, Rae Frances Bell, D. Aldington, Tudor J. C. Phillips, H. Gaskell, R. A. Moore   +7 more
semanticscholar   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Clinical translation of choline and geranic acid deep eutectic solvent

Bioengineering & Translational Medicine, 2021
Choline geranate deep eutectic solvent/ionic liquid (CAGE) has shown several desirable therapeutic properties including antimicrobial activity and ability to deliver drugs transdermally in research laboratories.
Justin Ko, Abhirup Mandal, Sunil Dhawan, Marina Shevachman, Samir Mitragotri, Nitin Joshi   +5 more
doaj   +1 more source