Results 51 to 60 of about 665,386 (338)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Topical non-steroidal immunomodulators in dermatology

Indian Dermatology Online Journal, 2023
Immunological abnormality is the pathological basis of many dermatological disorders. Although steroids are the backbone of topical therapy in dermatology, the side effects are encountered quite frequently.
Priya P Kadu
doaj   +1 more source

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

Molecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda, Marina Reguero, Vanesa Abón, Marta Puyol   +3 more
wiley   +1 more source

BERTopic: Neural topic modeling with a class-based TF-IDF procedure [PDF]

arXiv, 2022
Topic models can be useful tools to discover latent topics in collections of documents. Recent studies have shown the feasibility of approach topic modeling as a clustering task. We present BERTopic, a topic model that extends this process by extracting coherent topic representation through the development of a class-based variation of TF-IDF.
arxiv  

Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews.

Cochrane Database of Systematic Reviews, 2017
BACKGROUND Topical analgesic drugs are used for a variety of painful conditions. Some are acute, typically strains or sprains, tendinopathy, or muscle aches. Others are chronic, typically osteoarthritis of hand or knee, or neuropathic pain.
S. Derry, P. Wiffen, Eija A Kalso, Rae Frances Bell, D. Aldington, Tudor J. C. Phillips, H. Gaskell, R. A. Moore   +7 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Interventions in cytokine signaling: novel horizons for psoriasis treatment

Frontiers in Immunology
Intricate interactions between immune cells and cytokines define psoriasis, a chronic inflammatory skin condition that is immunological-mediated. Cytokines, including interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, and ...
Lisha Li, Lisha Li, Lisha Li, Jun Liu, Jun Liu, Jiaye Lu, Jiaye Lu, Junchao Wu, Junchao Wu, Xinyue Zhang, Xinyue Zhang, Tianyou Ma, Tianyou Ma, Xiying Wu, Xiying Wu, Quangang Zhu, Quangang Zhu, Zhongjian Chen, Zhongjian Chen, Zongguang Tai, Zongguang Tai   +20 more
doaj   +1 more source

Clinical translation of choline and geranic acid deep eutectic solvent

Bioengineering & Translational Medicine, 2021
Choline geranate deep eutectic solvent/ionic liquid (CAGE) has shown several desirable therapeutic properties including antimicrobial activity and ability to deliver drugs transdermally in research laboratories.
Justin Ko, Abhirup Mandal, Sunil Dhawan, Marina Shevachman, Samir Mitragotri, Nitin Joshi   +5 more
doaj   +1 more source

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

An Overview of Tissue Engineering as an Alternative for Toxicity Assessment

Journal of Pharmacy & Pharmaceutical Sciences, 2016
Tissue engineering is a multidisciplinary field that combines aspects of biology, material sciences, engineering and medicine - the ultimate goal being able to fabricate replacement tissues and/or organs for an ageing population.
Mathew Garrod, David Yi San Chau
doaj   +1 more source