Delivery of biologics: Topical administration. [PDF]
Biomaterials, 2023 Biologics are unaffordable to a large majority of the global population because of prohibitively expensive fermentation systems, purification and the requirement for cold chain for storage and transportation. Limitations of current production and delivery systems of biologics were evident during the recent pandemic when2.5% of vaccines produced were ...
Kulchar RJ +5 more
europepmc +4 more sources
A Review on the Role of Pilocarpine on the Management of Xerostomia and the Importance of the Topical Administration Systems Development [PDF]
Pharmaceuticals, 2022 Xerostomia is linked to an increased risk of dental caries, oral fungal infections, and speaking/swallowing difficulties, factors that may significantly degrade patients’ life, socially- or emotionally-wise.
Afroditi Kapourani +2 more
doaj +3 more sources
Systemic and topical administration of spermidine accelerates skin wound healing [PDF]
Cell Communication and Signaling, 2021 Background The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type plasminogen activator (uPA)/uPA ...
Daisuke Ito +5 more
doaj +3 more sources
Graphene Oxide Topical Administration: Skin Permeability Studies. [PDF]
Materials (Basel), 2021 Nanostructured carriers have been widely used in pharmaceutical formulations for dermatological treatment. They offer targeted drug delivery, sustained release, improved biostability, and low toxicity, usually presenting advantages over conventional formulations. Due to its large surface area, small size and photothermal properties, graphene oxide (GO)
Silva FALS +9 more
europepmc +9 more sources
Topical Administration of Mometasone Is Not Helpful in Post-COVID-19 Olfactory Dysfunction. [PDF]
Life (Basel), 2022 Persistent olfactory dysfunction is a major concern post-COVID-19, affecting up to 5% of all patients. Different therapeutic options, including mometasone nasal spray, have been recommended, only some of which have been validated for post-COVID-19 ...
Hintschich CA +3 more
europepmc +2 more sources
Effect of topical ketanserin administration on intraocular pressure. [PDF]
British Journal of Ophthalmology, 1993 The effect of topical ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes was evaluated. The study was performed on 10 healthy volunteers and 10 glaucomatous patients. Systolic arterial blood pressure (SBP), diastolic arterial blood pressure (DBP), heart rate (HR), IOP, tonographic outflow facility, pupil diameter, corneal ...
Ciro Costagliola +5 more
openalex +9 more sources
Plasma pharmacokinetics of tigolaner, emodepside, and praziquantel following topical administration of a combination product (Felpreva®) and of intravenous administration of the individual active ingredients in cats [PDF]
Current Research in Parasitology and Vector-Borne Diseases, 2023 Felpreva® for cats contains the new acaricidal/insecticidal active ingredient tigolaner in a fixed combination with the nematocidal and cestocidal compounds emodepside and praziquantel, respectively.
Norbert Mencke +5 more
doaj +3 more sources
TOPICAL ADMINISTRATION OF MEDICATIONS IN THE LUNGS
Journal of Clinical Pharmacy and Therapeutics, 1983 A survey has been carried out in Zimbabwe to gain information on pharmacist attitudes and current practice involving patient education in the use of medications for topical administration in the lung. The results of the survey indicated that although there was awareness of patient misuse of the administration devices, most pharmacists did not commonly ...
James C. McElnay, R. S. Summers
openalex +4 more sources
Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions [PDF]
Marine Drugs, 2022 Laminarin is a polysaccharide isolated from brown marine algae and has a wide range of bioactivities, including immunoregulatory and anti-inflammatory properties. However, the effects of laminarin on atopic dermatitis have not been demonstrated.
Tae-Kyeong Lee +10 more
doaj +2 more sources
BJS Open, 2019 Background Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is off‐label.
T. A. Eikebrokk +5 more
doaj +2 more sources