Delivery of biologics: Topical administration. [PDF]
Biomaterials, 2023 Biologics are unaffordable to a large majority of the global population because of prohibitively expensive fermentation systems, purification and the requirement for cold chain for storage and transportation. Limitations of current production and delivery systems of biologics were evident during the recent pandemic when 90% are delivered using invasive
Kulchar RJ +5 more
europepmc +5 more sources
Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions [PDF]
Marine Drugs, 2022 Laminarin is a polysaccharide isolated from brown marine algae and has a wide range of bioactivities, including immunoregulatory and anti-inflammatory properties. However, the effects of laminarin on atopic dermatitis have not been demonstrated.
Tae-Kyeong Lee +10 more
doaj +2 more sources
Acute Hyperglycemia Due to Topical Corticosteroid Administration
Case Reports in Endocrinology, 2019 We present the case of a 71-year-old man with longstanding, previously well-controlled type 1 diabetes who developed acute hyperglycemia. His insulin requirements, via his insulin pump, increased to nearly five times his typical daily dose.
Laura Y. Sue, Anna Milanesi
doaj +5 more sources
Graphene Oxide Topical Administration: Skin Permeability Studies [PDF]
Materials, 2021 Nanostructured carriers have been widely used in pharmaceutical formulations for dermatological treatment. They offer targeted drug delivery, sustained release, improved biostability, and low toxicity, usually presenting advantages over conventional formulations. Due to its large surface area, small size and photothermal properties, graphene oxide (GO)
Filipa A. L. S. Silva +9 more
openaire +3 more sources
Hyaluronic acid: perspectives in upper aero-digestive tract. A systematic review [PDF]
, 2015 Background: To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT).
Baptista, Peter +7 more
core +10 more sources
Cryoanesthesia with ethyl chloride spray versus 5% lidocaine gel in alleviating oral local anesthetic injection pain for buccal anaesthesia: A randomized clinical (controlled) trial [PDF]
Journal of Dental Research, Dental Clinics, Dental Prospects, 2023 Background. Numbing the area of oral mucosa with cold application prior to administration of regional anesthesia has been widely used by various dentists in alleviating pain caused by needle prick.
Hira Abbasi +5 more
doaj +1 more source
Pharmaceuticals, 2022 Xerostomia is linked to an increased risk of dental caries, oral fungal infections, and speaking/swallowing difficulties, factors that may significantly degrade patients’ life, socially- or emotionally-wise.
Afroditi Kapourani +2 more
doaj +1 more source
Topical (S)-ketamine for pain management of postherpetic neuralgia [PDF]
Anais Brasileiros de Dermatologia, 2012 Herpes zoster infection may cause postherpetic neuralgia, which is defined by prolonged pain predominantly mediated by central nervous system hypersensitivity.
Guilherme Antonio Moreira de Barros +4 more
doaj +1 more source
Topical ocular delivery of nanoparticles with epoetin beta in Wistar Hannover rats
Scientific Reports, 2023 Topical instillation of drugs targeting the posterior ocular segment is an expanding area of research. Chitosan and hyaluronic acid have remarkable mucoadhesive properties and potentially enhance pre-corneal retention time after topical instillation ...
Beatriz Silva +3 more
doaj +1 more source
Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility
BMC Veterinary Research, 2021 Background Topical ophthalmic atropine sulfate is an important part of the treatment protocol in equine uveitis. Frequent administration of topical atropine may cause decreased intestinal motility and colic in horses due to systemic exposure.
L. Ström +7 more
doaj +1 more source