Delivery of biologics: Topical administration. [PDF]
Biologics are unaffordable to a large majority of the global population because of prohibitively expensive fermentation systems, purification and the requirement for cold chain for storage and transportation. Limitations of current production and delivery systems of biologics were evident during the recent pandemic when 90% are delivered using invasive
Kulchar RJ+5 more
europepmc +5 more sources
Effect of topical ketanserin administration on intraocular pressure. [PDF]
The effect of topical ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes was evaluated. The study was performed on 10 healthy volunteers and 10 glaucomatous patients. Systolic arterial blood pressure (SBP), diastolic arterial blood pressure (DBP), heart rate (HR), IOP, tonographic outflow facility, pupil diameter, corneal ...
Ciro Costagliola+5 more
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TOPICAL ADMINISTRATION OF MEDICATIONS IN THE LUNGS
A survey has been carried out in Zimbabwe to gain information on pharmacist attitudes and current practice involving patient education in the use of medications for topical administration in the lung. The results of the survey indicated that although there was awareness of patient misuse of the administration devices, most pharmacists did not commonly ...
James C. McElnay, Richard Summers
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A Review on the Role of Pilocarpine on the Management of Xerostomia and the Importance of the Topical Administration Systems Development [PDF]
Xerostomia is linked to an increased risk of dental caries, oral fungal infections, and speaking/swallowing difficulties, factors that may significantly degrade patients’ life, socially- or emotionally-wise.
Afroditi Kapourani+2 more
doaj +2 more sources
Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions [PDF]
Laminarin is a polysaccharide isolated from brown marine algae and has a wide range of bioactivities, including immunoregulatory and anti-inflammatory properties. However, the effects of laminarin on atopic dermatitis have not been demonstrated.
Tae-Kyeong Lee+10 more
doaj +2 more sources
Transdermal and Topical Drug Administration in the Treatment of Pain [PDF]
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients’ age, comorbidities, and appropriate choice of analgesic, its dose and route of administration.
Wojciech Leppert+3 more
openalex +6 more sources
Acute Hyperglycemia Due to Topical Corticosteroid Administration
We present the case of a 71-year-old man with longstanding, previously well-controlled type 1 diabetes who developed acute hyperglycemia. His insulin requirements, via his insulin pump, increased to nearly five times his typical daily dose.
Laura Y. Sue, Anna Milanesi
doaj +6 more sources
Cryoanesthesia with ethyl chloride spray versus 5% lidocaine gel in alleviating oral local anesthetic injection pain for buccal anaesthesia: A randomized clinical (controlled) trial [PDF]
Background. Numbing the area of oral mucosa with cold application prior to administration of regional anesthesia has been widely used by various dentists in alleviating pain caused by needle prick.
Hira Abbasi+5 more
doaj +1 more source
Topical (S)-ketamine for pain management of postherpetic neuralgia [PDF]
Herpes zoster infection may cause postherpetic neuralgia, which is defined by prolonged pain predominantly mediated by central nervous system hypersensitivity.
Guilherme Antonio Moreira de Barros+4 more
doaj +1 more source
mTHPC pharmacokinetics following topical administration [PDF]
Measurements of concentration of sensitizers for photodynamic therapy can provide important information in the dosimetry planning and can also give input to the optimal time for treatment. There has been skepticism towards fluorescence techniques for this purpose, as the signal depends on the fluorescence yield and optical properties of the tissue ...
Johansson, Ann+10 more
openaire +3 more sources