A Review on the Role of Pilocarpine on the Management of Xerostomia and the Importance of the Topical Administration Systems Development [PDF]
Pharmaceuticals, 2022 Xerostomia is linked to an increased risk of dental caries, oral fungal infections, and speaking/swallowing difficulties, factors that may significantly degrade patients’ life, socially- or emotionally-wise.
Afroditi Kapourani +2 more
doaj +3 more sources
Delivery of biologics: Topical administration. [PDF]
Biomaterials, 2023 Biologics are unaffordable to a large majority of the global population because of prohibitively expensive fermentation systems, purification and the requirement for cold chain for storage and transportation. Limitations of current production and delivery systems of biologics were evident during the recent pandemic when 90% are delivered using invasive
Kulchar RJ +5 more
europepmc +6 more sources
Nanostructured Lipid Carriers Enriched Hydrogels for Skin Topical Administration of Quercetin and Omega-3 Fatty Acid. [PDF]
Pharmaceutics, 2023 Chronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging.
Lúcio M +11 more
europepmc +2 more sources
Topical Administration of Mometasone Is Not Helpful in Post-COVID-19 Olfactory Dysfunction. [PDF]
Life (Basel), 2022 Persistent olfactory dysfunction is a major concern post-COVID-19, affecting up to 5% of all patients. Different therapeutic options, including mometasone nasal spray, have been recommended, only some of which have been validated for post-COVID-19 ...
Hintschich CA +3 more
europepmc +2 more sources
Systemic and topical administration of spermidine accelerates skin wound healing
Cell Communication and Signaling, 2021 Background The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type plasminogen activator (uPA)/uPA ...
Daisuke Ito +5 more
doaj +2 more sources
Scientifica, 2022 This research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing.
Dwi Winarni +10 more
doaj +2 more sources
BJS Open, 2019 Background Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is off‐label.
T. A. Eikebrokk +5 more
doaj +2 more sources
Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions [PDF]
Marine Drugs, 2022 Laminarin is a polysaccharide isolated from brown marine algae and has a wide range of bioactivities, including immunoregulatory and anti-inflammatory properties. However, the effects of laminarin on atopic dermatitis have not been demonstrated.
Tae-Kyeong Lee +10 more
doaj +2 more sources
Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice [PDF]
Frontiers in Neuroscience, 2019 Background Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation.
Minna Yli-Karjanmaa +10 more
openalex +2 more sources
Experimental colitis in mice is attenuated by topical administration of chlorogenic acid [PDF]
Naunyn-Schmiedeberg's Archives of Pharmacology, 2015 Epidemiological data suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease, and inflammation. Chlorogenic acid (CGA), an ester of caffeic and quinic acids, is one of the most abundant polyphenol ...
Hubert Zatorski +8 more
openalex +2 more sources