Results 21 to 30 of about 149,732 (304)

Evidence of Cannabidiol Effectiveness Associated or Not with Tetrahydrocannabinol in Topical Administration: A Scope Review [PDF]

Pharmaceuticals
Ana Laura Masquetti Fava, Cinthia Madeira De Souza, Erica Mendes Dos Santos   +2 more
exaly   +1 more source

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

Journal of Pharmacological Sciences, 2008
A pain model for screening analgesics was established in anesthetized rats. The omenta of urethane-anesthetized rats were exteriorized, fixed in a plastic chamber, and superfused with Tyrode solution.
Shi-Jie Yang, Makoto Katori, Masataka Majima   +2 more
doaj   +1 more source

In Vivo Evaluation of Cefuroxime Axetil-Loaded Bioadhesive Nanoparticles to Treat Haemophilus influenzae-Induced Otitis Media

Frontiers in Bioengineering and Biotechnology, 2022
Otitis media (OM) is a common disease in children. One of the most common pathogens causing OM is non-typeable Haemophilus influenzae (NTHi). NTHi in the middle ear can be successfully eradicated by a regimen of oral antibiotics sustained for 7–10 days ...
Hong Lin, Yizhen Jia, Xiaohan Kong, Shiting Wang, Xiangyou Liu, Yang Liu, Yang Deng   +6 more
doaj   +1 more source

Ice versus lidocaine 5% gel for topical anaesthesia of oral mucosa – a randomized cross-over study

BMC Anesthesiology, 2019
Background Topical anaesthesia is important to optimize pain control during dental injection. Our aim was to describe a new simple method for topical anaesthesia of oral mucosa and to compare the effectiveness of ice and lidocaine 5% gel for topical ...
Nishma Hindocha, Filip Manhem, Emmanuel Bäckryd, Mats Bågesund   +3 more
doaj   +1 more source

Comparison of topical and intravenous tranexamic acid for reducing postoperative blood loss in single-level posterior lumbar interbody fusion: a retrospective study from Japan [PDF]

Asian Spine Journal
Study Design A retrospective cohort study. Purpose This study aimed to compare the efficacy and safety of topical and relatively high-dose intravenous tranexamic acid (TXA) in minimizing postoperative blood loss in patients undergoing single-level ...
Kazuma Kitaguchi, Kunihiko Hashimoto, Takashi Kaito, Kazuya Oshima, Eiji Wada   +4 more
doaj   +1 more source

Polymeric Biomaterials for Topical Drug Delivery in the Oral Cavity: Advances on Devices and Manufacturing Technologies

Pharmaceutics, 2022
There are several routes of drug administration, and each one has advantages and limitations. In the case of the topical application in the oral cavity, comprising the buccal, sublingual, palatal, and gingival regions, the advantage is that it is ...
Paula de Freitas Rosa Remiro, Mariana Harue Taniguchi Nagahara, Rafael Abboud Azoubel, Michelle Franz-Montan, Marcos Akira d’Ávila, Ângela Maria Moraes   +5 more
doaj   +1 more source

Effects of Eye Drops Containing Hyaluronic Acid-Nimesulide Conjugates in a Benzalkonium Chloride-Induced Experimental Dry Eye Rabbit Model

Pharmaceutics, 2021
Dry eye syndrome (DES) is a common ocular disease worldwide. Currently, anti-inflammatory agents and immunosuppressive drugs, such as cyclosporine A, have been widely used to treat this chronic condition. However, the multifactorial etiology of DES, poor
Tzu-Yang Chen, Ching-Li Tseng, Chih-An Lin, Hua-Yang Lin, Parthiban Venkatesan, Ping-Shan Lai   +5 more
doaj   +1 more source

The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty

Journal of Orthopaedic Surgery, 2017
Aims: The combined (IV (intravenous) + topical) use of tranexamic acid (TXA) has been shown to be a safe method and more effective than single (IV or topical) application.
Deniz Cankaya, Uygar Dasar, Ahmet Burak Satilmis, Serdar Hakan Basaran, Mustafa Akkaya, Murat Bozkurt   +5 more
doaj   +1 more source

Norcantharidin Nanoemulsion Development, Characterization, and In Vitro Antiproliferation Effect on B16F1 Melanoma Cells

Pharmaceuticals, 2023
Melanoma is a highly lethal type of cancer that has had an increase in incidence in the last decades. Nevertheless, current therapies lack effectiveness and have highly disabling side effects, which calls for new therapeutic strategies.
Gabriel Martínez-Razo, Patrícia C. Pires, María Lilia Domínguez-López, Francisco Veiga, Armando Vega-López, Ana Cláudia Paiva-Santos   +5 more
doaj   +1 more source

Transdermal and Topical Drug Administration in the Treatment of Pain [PDF]

Molecules, 2018
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients’ age, comorbidities, and appropriate choice of analgesic, its dose and route of administration.
Wojciech Leppert, Malgorzata Malec–Milewska, Renata Zajaczkowska, Jerzy Wordliczek   +3 more
openaire   +4 more sources