Results 181 to 190 of about 28,018 (262)

Source-level α periodic power in visual and default mode networks predicts topiramate treatment response in migraine. [PDF]

J Headache Pain
Xie S, Pi C, Jin K, Ma L, Huo Y, Hu M, Zhang X, Tai S, Lin J, Yu S, Ran Y, Dong Z.   +11 more
europepmc   +1 more source

Serum Concentration Relationships of Candesartan in Migraine Prevention

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Migraine is a common disabling disorder, and optimising affordable preventive treatments remains highly relevant. Candesartan is an effective and well‐tolerated preventive treatment, but little is known about its dose‐concentration–response relationships.
Hedda Skogum Riise, Melanie Simpson, Ketil Arne Espnes, Erling Andreas Tronvik, Andreas Kattem Husøy, Lise R. Øie, Anker Stubberud, Emil Kofoed, Aurora Harsvik Alstad, Hedda Hoff Hagen, Maren Guldteig Lien, Marie Larsen Stavseng, Ella Rian Sæther, Tore Wergeland   +13 more
wiley   +1 more source

Cost-Utility Analysis of Calcitonin Gene-Related Peptide Monoclonal Antibodies for Patients with Episodic Migraine Headache in the USA. [PDF]

Pharmacoeconomics
Dong AW, Bounthavong M.
europepmc   +1 more source

Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6‐Month Claims Database Analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9966-9979, November 2026.
ABSTRACT Aims Tirzepatide is a once‐weekly glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) approved in the US for the treatment of Type 2 diabetes (T2D), weight loss and obstructive sleep apnoea. This study aimed to assess the utilisation and effectiveness of tirzepatide among individuals in a large ...
Theresa Hunter Gibble, Malvika Venkataraman, Donna Mojdami, Carlos Vallarino, Grace Stockbower, Michael Grabner, Mythili Ananth, Karishma Desai   +7 more
wiley   +1 more source

Prophylactic efficacy and safety of valproate versus topiramate for migraine: a systematic review. [PDF]

BMC Neurol
Wasti SA, Wasti A, Abid MA, Shahid MS, Kuo VFH, Cano-Reyes SE, Iqbal MU, Vasylyshyn A, Krymchantowski AV.   +8 more
europepmc   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Pharmacotherapy for Children and Adolescents With Overweight or Obesity: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. [PDF]

Diabetes Obes Metab
Luo L, Huang T, Yan Z, Qi Y, Wei Q, Wang H, Liu N, Xuan Y, Chen Y, Zhao J, Xin C, Hu R, Zhang S.   +12 more
europepmc   +1 more source

Subclinical Cerebral Lesions in Migraine: A Proof‐of‐Concept Study on Platelet Aggregation

European Journal of Neurology, Volume 33, Issue 11, November 2026.
We assessed platelet aggregation in patients with migraine (n = 34) with or without cerebral white‐matter lesions (WMLs) versus matched controls (n = 34), with WMLs volume quantified by MRI (mm3). Aggregation to ADP, collagen, epinephrine, and arachidonic acid was measured; epinephrine‐induced aggregation at 1.25–2.5 μM was overall lower in migraine ...
Ilaria Maestrini, Mariaignazia Curreli, Marta Puma, Costanza Giannì, Eleonora Schiera, Giada Giuliani, Massimiliano Toscano, Marta Altieri, Patrizia Pantano, Fabio Pulcinelli, Vittorio Di Piero   +10 more
wiley   +1 more source

Structural basis for activation and potentiation in a human α5β3 GABA_A receptor. [PDF]

Nat Commun
Cowgill J, Fan C, Steyaert J, Howard RJ, Lindahl E.   +4 more
europepmc   +1 more source

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case–control study

Headache: The Journal of Head and Face Pain, Volume 66, Issue 10, Page 2337-2349, November/December 2026.
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber, Roemer B. Brandt, Mariël Leon Morales‐Grooters, Ronald van der Wal, Sjoerd A. A. van den Berg, Jelle J. Goeman, Antoinette Maassen van den Brink, Rolf Fronczek   +7 more
wiley   +1 more source