Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Antibody‐drug conjugates (ADCs) have evolved in the last decade or two from carrying a single chemotherapy payload to carrying highly potent tubulin inhibitors and DNA damaging agents. While the latter have shown success in the clinic, efficacy has been constrained by therapeutic resistance, limited tumor penetration, and suboptimal immune ...
Paulien Ravenstijn +5 more
wiley +1 more source
Polarisation through deviation discourse: strategic usage of Europeanisation by political and media actors in Georgia. [PDF]
East Eur PolitTsuladze L, Abzianidze N.
europepmc +1 more source
Sequencing Antibody Drug Conjugates in Breast Cancer: Exploring Future Roles. [PDF]
Curr Oncol, 2023 Fenton MA, Tarantino P, Graff SL.
europepmc +1 more source
Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts
Genes to Cells, Volume 31, Issue 3, May 2026.Histone chaperones and chromatin remodelers modulate histone density and dynamics. The resulting local chromatin properties are integrated with DNA reconfiguration activities mediated by condensins and topoisomerase IIα to shape the global architecture of mitotic chromosomes.
Keishi Shintomi +3 more
wiley +1 more source
Differential roles of positive and negative supercoiling in organizing the E. coli genome. [PDF]
Nucleic Acids ResFu Z, Guo MS, Zhou W, Xiao J.
europepmc +1 more source
Narrative formatting, chronotopic orderings, and moralization in ex‐gay stories
Journal of Linguistic Anthropology, Volume 36, Issue 1, May 2026.Abstract Formatted stories rely on spatiotemporal cues to evoke recognizability through linearity, which prescribes a particular template for meaning‐making. This article examines stories narrated by ex‐gay members of a Christian organization in Singapore and considers how chronotopes within the stories are ordered to regiment ways of feeling for ...
Vincent Pak
wiley +1 more source
Steering the Shape‐shifting of Bullvalene‐PdII Complexes Through Steric and Geometric Strain
Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.This study explores the use of bis‐pyridyl substituted bullvalenes as dynamic shape‐shifting ligands within cis‐capped PdII complexes. The ring position of the pyridyl nitrogen is critical, leading to a range of Pd2L2 metallacycles and simple PdL complexes, each with distinctive bullvalene isomer preferences (represented in the figure by A‐D isomer ...
André P. Birvé +2 more
wiley +2 more sources
Genetic Variation in Chemical Defence Affects Protection of an Herbivorous Insect Against Predation
Molecular Ecology, Volume 35, Issue 9, May 2026.ABSTRACT Genetic variation contributes to intraspecific differences in the chemical defence in many insect species, yet the underlying genetic mechanisms remain poorly understood. The horseradish flea beetle, Phyllotreta armoraciae, sequesters glucosinolates from its horseradish host plant and activates them using endogenous myrosinase enzymes.
Johannes Körnig +9 more
wiley +1 more source
Capturing Argument in Agent-Based Models. [PDF]
Topoi (Dordr)Assaad L +4 more
europepmc +1 more source