Results 221 to 230 of about 60,395 (277)

Blue Fluorescent Siloxytecans Exhibit Potent Anticancer Activity and Enable Direct Real-Time Quantification of Intracellular Uptake. [PDF]

ACS Bio Med Chem Au
Lo I, Vaidya S, Mo A, Chia AY, Li K, Parvin J, Sadagopan S, D'souza Z, Kwok O, Zhang J, Baratoff I, Somani S, Menta L, Xie Y, Sanchez T, Wang T, Chen R, Yamamoto A, Pazzi J, Njoo E.   +19 more
europepmc   +1 more source

A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review. [PDF]

Cancer Med
Kotian N, Reddy Y, Pai P, Sundara BK.
europepmc   +1 more source

Activities of the Novel Bacterial Topoisomerase Inhibitor OSUAB-0284 against the Biothreat Pathogen <i>Bacillus anthracis</i> and Its Type II Topoisomerases. [PDF]

ACS Infect Dis
Mann CA, Halasohoris SA, Gray AM, Chua J, Spencer JL, Curry BJ, Babyak AL, Klimko CP, Cote CK, West JS, Mitton-Fry MJ, Meinig JM, Osheroff N.   +12 more
europepmc   +1 more source

Quinoxaline Derivatives in Cancer Therapy: Insights into Mechanisms of Action and Therapeutic Applications. [PDF]

Biomol Ther (Seoul)
Alhuwayshil J, Alnajim N, Dulaym SB, Alamre J, Alsubait A, Mohammed AE, Alghamdi SS.   +6 more
europepmc   +1 more source

Pharmacologic modulation of topoisomerase I inhibitors

, 2001
openaire   +1 more source

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TOPOISOMERASE-I INHIBITORS IN GYNECOLOGIC TUMORS

Hematology/Oncology Clinics of North America, 1999
The first section of this article reviews recent studies that have clarified both the cellular role of topoisomerase I and the mechanisms of cytotoxicity of the topoisomerase inhibitors, the camptothecins. Different analogs of this new class of antitumor drug have been studied using various dose schedules in the treatment of refractory or recurrent ...
P, Haluska, E, Rubin, C F, Verschraegen
openaire   +2 more sources

Edotecarin: A Novel Topoisomerase I Inhibitor

Clinical Colorectal Cancer, 2005
Edotecarin (PHA-782615; formerly J-107088) is a derivative of NB-506, an indolocarbazole antitumor agent. It is a novel inhibitor of topoisomerase I that induces single-strand DNA cleavage more effectively than NB-506 or camptothecin (CPT) and at different DNA sequences. The DNA-topoisomerase I complexes induced by edotecarin are more stable than those
M Wasif, Saif, Robert B, Diasio
openaire   +2 more sources

DNA Topoisomerase I Inhibitors from Rinorea anguifera.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ji, Ma, Shannon H, Jones, Rebekah, Marshall, Xihan, Wu, Sidney M, Hecht   +4 more
openaire   +2 more sources