Results 91 to 100 of about 5,862,089 (150)

A Rationally Engineered Norfloxacin-Phenoxazine Hybrid as a Dual-Function Anticancer Agent: DNA Intercalation Synergizes with Topoisomerase II Inhibition against Murine Breast Tumor. [PDF]

ACS Med Chem Lett
Roy R, Ria T, Das K, Patial V, Das G, Sk UH.   +5 more
europepmc   +1 more source

Phytochemical profiling of Pleurospermum candollei flowers and stems reveals antioxidant constituents with topoisomerase II-targeted anticancer potential. [PDF]

Sci Rep
Hussain N, Batool S, Ullah A, Halim SA, Ali B, Ali S, Alamgir M, Abbas Z, Uddin J, Muhsinah AB, Khan A, Al-Harrasi A.   +11 more
europepmc   +1 more source

DNA Lesions as Cellular Poisons of Topoisomerase II-alpha

, 2005
Topoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low levels under normal conditions ...
Velez-Cruz, Renier
core  

A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review. [PDF]

Cancer Med
Kotian N, Reddy Y, Pai P, Sundara BK.
europepmc   +1 more source

Aotaphenazine, a rare hydrophenazine, targets topoisomerase II with anticancer efficacy: In silico to in vitro evidence. [PDF]

PLoS One
Metwaly AM, Eissa IH, Afifi WM, Elkaeed EB, Alsfouk AA, Ibrahim IM, Abdelfattah MS.   +6 more
europepmc   +1 more source

Cotargeting DNA topoisomerase II enhances efficacy of RAS-targeted therapy in KRAS-mutant cancer models. [PDF]

J Clin Invest
Xu R, Wang D, Ma G, Yuan X, Chu Q, Fan S, Zhang R, Du P, Jia S, Leal TA, Ramalingam SS, Chen Z, Sun SY.   +12 more
europepmc   +1 more source

Topoisomerase II binding protein 1-interacting checkpoint and replication regulator promotes lung adenocarcinoma proliferation by regulating myelocytomatosis oncogene signaling pathway. [PDF]

Cytojournal
Zhao Y, Feng Y, Guo M, Li L.
europepmc   +1 more source

Leveraging topoisomerase II-mediated DNA damage: repurposing etoposide as a lead compound for apicomplexan parasite control. [PDF]

Front Vet Sci
Li Y, Cui Z, Li J, Zhang Y, Zafar I, Rizk MA, Li H, El-Sayed SAE, Yokoyama N, Guo Q, Xuan X, Chahan B.   +11 more
europepmc   +1 more source

Anticancer drugs targeting topoisomerase II for antifungal treatment. [PDF]

Sci Rep
Kondaka K, Rząd K, Maciejewska N, Gabriel I.   +3 more
europepmc   +1 more source

Conformations of the three gates in Saccharomyces cerevisiae topoisomerase II and their response to DNA, nucleotide, and etoposide. [PDF]

J Biol Chem
Stelljes JT, Klostermeier D.
europepmc   +1 more source