Results 71 to 80 of about 5,862,089 (150)
Acrylamide catalytically inhibits topoisomerase II in V79 cells
, 2010 The vinyl monomer acrylamide is characterized by the presence of an alpha,beta-unsaturated carbonyl group that makes it reactive towards thiol, hydroxyl or amino groups and towards the nucleophilic centers in DNA.
CARADONNA, Fabio +5 more
core +1 more source
, 2016 Topoisomerase II modulates DNA topology by generating double-stranded breaks in DNA. Results of the current study indicate that the presence of a nick at one scissile bond dramatically increases the rate of cleavage by human topoisomerase IIα at the ...
Neil Osheroff (16602) +1 more
core +1 more source
Single-molecule FRET–based approach for protein-targeted drug discovery
Molecules and Cells: Many therapeutic drugs target various proteins involved in diverse biological processes. Among these proteins, type II topoisomerases are critical targets for anticancer and antibacterial chemotherapies, yet the action mechanisms of many type II ...
Yuyoung Kim +3 more
doaj +1 more source
A novel homogenous assay for topoisomerase II action and inhibition
, 2005 Topoisomerase II is the only enzyme able to cleave and religate double-stranded DNA; this makes it essential for many vital functions during normal cell growth.
Jahnz, M., Schwille, P., Medina, M.
core +1 more source
TOPOISOMERASE-I AND TOPOISOMERASE-II ACTIVITY IN HUMAN BREAST, CERVIX, LUNG AND COLON-CANCER
, 1994 The identification of human DNA topoisomerases as cellular targets for active anti-cancer drugs has stimulated further interest in topoisomerase function in tumour biology.
SYMONDS, RP +8 more
core +1 more source
Benzothiazole derivatives as human DNA topoisomerase II alpha inhibitors
, 2013 Benzothiazole derivatives resembling the structure of DNA purine bases were tested to determine their topoisomerase inhibition activities. Based on DNA topoisomerase I and II relaxation assay results, all 12 derivatives acted as human topoisomerase II ...
Aki, Esin +6 more
core +1 more source
Design, synthesis and in vitro anticancer activity of some new lomefloxacin derivatives
Scientific ReportsOur main goal was to design and synthesize novel lomefloxacin derivatives that inhibit the topoisomerase II enzyme, leading to potent anticancer activity.
Mina E. Adly +3 more
doaj +1 more source
Determination of Decatenation Activity of Topoisomerase II Mutant Alleles
, 2013 iv, 45 p.Topoisomerases are the magicians of the DNA world, functioning as enzymes to decatenate, or unlink, DNA. Topoisomerase II is the enzyme responsible for unlinking double stranded DNA, which is crucial for segregation of sister chromatids in ...
Gillentine, Madelyn A.
core +1 more source
Autoantibodies to DNA topoisomerase II in juvenile rheumatoid arthritis
, 1991 SUMMARY Sera from 58 children with juvenile rheumatoid arthritis were examined for the presence of antibodies to DNA topoisomerase II. Eight sera were reactive in immunoblotting with purified human topoisomerase II and a protein encoded by
I S SZER, W SZER, K L ZUKLYS
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Pulmonary arterial hypertension (PAH) is a progressive disease driven by pulmonary vascular remodeling, largely due to the abnormal proliferation and phenotypic switching of pulmonary artery smooth muscle cells. Methods Levels of topoisomerase
Yong‐Jian Zhu +13 more
doaj +1 more source