Results 51 to 60 of about 5,862,089 (150)

Antibacterial activity of a DNA topoisomerase I inhibitor versus fluoroquinolones in Streptococcus pneumoniae.

PLoS ONE, 2020
The DNA topoisomerase complement of Streptococcus pneumoniae is constituted by two type II enzymes (topoisomerase IV and gyrase), and a single type I enzyme (topoisomerase I).
Myriam V Valenzuela, Mirian Domenech, Patricia Mateos-Martínez, Fernando González-Camacho, Adela G de la Campa, Maria Teresa García   +5 more
doaj   +1 more source

Cryo-EM structures of African swine fever virus topoisomerase

mBio, 2023
Type II topoisomerases ubiquitously exist in cellular organisms, where they play an essential role in resolving the topological problems of DNA. The viral type II topoisomerase encoded by the African swine fever virus (ASFV) is critical for viral ...
Yan Zhao, Wenhua Kuang, Qiyin An, Jinyue Li, Yong Wang, Zengqin Deng   +5 more
doaj   +1 more source

Insights into idarubicin antimicrobial activity against methicillin-resistant Staphylococcus aureus

Virulence, 2020
Background MRSA is a major concern in community settings and in health care. The emergence of biofilms and persister cells substantially increases its antimicrobial resistance.
Pengfei She, Shijia Li, Linying Zhou, Zhen Luo, Jinfeng Liao, Lanlan Xu, Xianghai Zeng, Ti Chen, Yaqian Liu, Yong Wu   +9 more
doaj   +1 more source

Topoisomerase II inhibition involves characteristic chromosomal expression patterns

BMC Genomics, 2008
Background The phenomenon of co-localization of transcriptionally upregulated genes showing similar expression levels is known across all eukaryotic genomes.
Borlak Jürgen, Reymann Susanne
doaj   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

HYPERTHERMIA, THERMOTOLERANCE AND TOPOISOMERASE-II INHIBITORS

, 1995
The cytoxicity of both intercalating (m-AMSA) and non-intercalating (VP16, VM26) topoisomerase II-targeting drugs is thought to occur via trapping DNA topoisomerase II on DNA in the form of cleavable complexes.
HH Kampinga, KAMPINGA, HH; id_orcid, KAMPINGA, HH   +2 more
core   +2 more sources

Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells

Biology Open, 2015
We report the whole genome ChIP seq for human TOP2B from MCF7 cells. Using three different peak calling methods, regions of binding were identified in the presence or absence of the nuclear hormone estradiol, as TOP2B has been reported to play a role in ...
Catriona M. Manville, Kayleigh Smith, Zbyslaw Sondka, Holly Rance, Simon Cockell, Ian G. Cowell, Ka Cheong Lee, Nicholas J. Morris, Kay Padget, Graham H. Jackson, Caroline A. Austin   +10 more
doaj   +1 more source

Caracterização das DNA topoisomerases II de Trypanosoma rangeli [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2010DNA topoisomerases são enzimas que participam de diversos processos celulares tais como: replicação ...
Stoco, Patrícia Hermes
core  

Topoisomerase II and leukemia

, 2014
Type II topoisomerases are essential enzymes that modulate DNA under- and overwinding, knotting, and tangling. Beyond their critical physiological functions, these enzymes are the targets for some of the most widely prescribed anticancer drugs ...
Lindsey, R. Hunter, MaryJean Pendleton, R. Hunter Lindsey, Carolyn A. Felix, Neil Osheroff, Grimwade, David, David Grimwade, Pendleton, Maryjean, Felix, Carolyn A., Osheroff, Neil   +9 more
core   +1 more source

Molecular docking, QSAR, and ADME studies of some pyrrolo[1, 2-a] benzimidazole-based quinones as novel topoisomerase 2 beta (TOP2β) inhibitors

Chemical Physics Impact
In recent years, selective topoisomerase II inhibitors have drawn interest in the development of novel antitumor compounds to an extraordinary degree. As potent topoisomerase II inhibitors, pyrrolo[1, 2-a]-benzimidazole quinones with a 6-aziridinyl group
Rahul D. Jawarkar, Anam N. Khan, Dhanashri R. Bhagat, Pravin N. Khatale, Pramod V. Burakale, Saleemuddin Farooqui, Suraj N. Mali   +6 more
doaj   +1 more source