Results 61 to 70 of about 5,862,089 (150)

Purification and functional characterization of type II DNA topoisomerase from rat testis and comparison with topoisomerase II from liver

, 1996
A number of studies in yeast have shown that DNA topoisomerase II is essential for chromosome condensation and disjunction during mitosis at the metaphase/anaphase transition and meiosis I. Accordingly, kinetic and mechanistic studies have implied a role
Muniyappa, K., Galande, Sanjeev
core   +2 more sources

Potential role for the Metnase transposase fusion gene in colon cancer through the regulation of key genes.

PLoS ONE, 2014
The Metnase fusion gene consists of a SET histone methyltransferase domain and a transposase domain from Mariner transposase. This transposable element is involved in chromosome decatenation, enhances DNA repair, promotes foreign DNA integration, and ...
Panagiotis Apostolou, Maria Toloudi, Eleni Kourtidou, Georgia Mimikakou, Ioanna Vlachou, Marina Chatziioannou, Vasiliki Kipourou, Ioannis Papasotiriou   +7 more
doaj   +1 more source

Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase

mBio
Type II topoisomerase utilizes the energy from ATP hydrolysis to alter DNA topology during genome replication and transcription. The ATPase domain of this enzyme is required for ATP hydrolysis and plays a crucial role in coupling DNA binding and ATP ...
Wenhua Kuang, Yan Zhao, Jinyue Li, Zengqin Deng   +3 more
doaj   +1 more source

Topoisomerase II, not topoisomerase I, is the proficient relaxase of nucleosomal DNA [PDF]

, 2015
Eukaryotic topoisomerases I and II efficiently remove helical tension in naked DNA molecules. However, this activity has not been examined in nucleosomal DNA, their natural substrate.
Fernàndez, Xavier, Salceda, Javier, Roca, Joaquim   +2 more
core   +1 more source

Crystal Structures of the 43 kDa ATPase Domain of Xanthomonas Oryzae pv. Oryzae Topoisomerase IV ParE Subunit and its Complex with Novobiocin

Crystals, 2019
Topoisomerase IV, one of the best-established antibacterial targets, is an enzyme crucial for chromosome segregation and cell division by catalyzing changes in DNA topology through breaking and rejoining DNA.
Ha Yun Jung, Yong-Seok Heo
doaj   +1 more source

The topoisomerase II–Hsp90 complex: A new chemotherapeutic target?

, 2006
The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new
Jenkins, John R., Barker, Catherine R., Hamlett, Jane, Pennington, Stephen R., Watson, Alastair J M, Lundgren, Karen, Burrows, Francis, Lough, Rachel   +7 more
core   +1 more source

Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.

, 2013
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth leading cause of cancer death in the western world, with a 5-year survival rate below 5%.
Conradt, Laura;Henrich, Annika;Wirth, Matthias;Reichert, Maximilian;Lesina, Marina;Algül, Hana;Schmid, Roland M;Krämer, Oliver H;Saur, Dieter;Schneider, Günter
core   +1 more source

DNA topoisomerase II in therapy-related acute promyelocytic leukemia

, 2005
Background: Chromosomal translocations leading to chimeric oncoproteins are important in leukemogenesis, but how they form is unclear. We studied acute promyelocytic leukemia (APL) with the t(15;17) translocation that developed after treatment of breast ...
Reiter, Andreas, Adès, Lionel, Whitmarsh, Ryan J., Segal, Mark R., Cassinat, Bruno, Grimwade, David, Fenaux, Pierre, Felix, Carolyn A., Osheroff, Neil, Cross, Nicholas C.P., Lafage-Pochitaloff, Marina, Chomienne, Christine, Parry, Anne, Walz, Christoph, Mason, Annabel, Wiemels, Joseph L., Blair, Ian A., Mistry, Anita R., Peniket, Andrew J., Solomon, Ellen   +19 more
core   +2 more sources

Exploring the Role of Topoisomerase II Beta in Macrophage Maturation and Pro-inflammatory Cytokine Production [PDF]

Although it is known that DNA topo IIβis required for the regulation of transcription during neural development and differentiation, it is not clear whether the enzyme is required during differentiation of human monocytes into macrophages and/or the ...
Roythorne, Ashleigh
core  

Topoisomerase II is differentially required for meiotic chromosome morphology in spermatogenesis and oogenesis

Jaramillo-Lambert, AimeeInfertility is a common and world-wide health issue that can be devastating to affected couples. The rate of infertility is between 5% to 15% in both developed and under-developed nations.
Rourke, Christine Kiely
core   +1 more source